Chen Haiyan, Wang Jing, Zhou Wang, Yin Huabin, Wang Meimei
From the Division of Rheumatology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing; Department of Anatomy and Histoembryology, Xuzhou Medical College, Xuzhou; Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.H. Chen, MM, Division of Rheumatology, Zhongda Hospital, School of Medicine, Southeast University; J. Wang, MD, Department of Anatomy and Histoembryology, Xuzhou Medical College, and Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University; W. Zhou, PhD; H. Yin, PhD, Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University; M. Wang, MM, Division of Rheumatology, Zhongda Hospital, School of Medicine, Southeast University.
J Rheumatol. 2015 Sep;42(9):1563-9. doi: 10.3899/jrheum.150195. Epub 2015 Jul 15.
Previous studies have examined the association between breastfeeding and rheumatoid arthritis (RA), but their results were inconsistent. The aim of this study was to perform a metaanalysis to clarify the effect of breastfeeding on RA risk.
The PubMed, EMBASE, Chinese National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies published up to September 10, 2014. Data were extracted, and multivariable-adjusted OR with 95% CI were pooled in the random-effects model.
A total of 6 studies were included in the metaanalysis (RA cases: 1672, sample size: 143,670). Overall, an inverse association between breastfeeding and RA was observed (OR 0.675, 95% CI 0.493-0.924, p = 0.014). In the subgroup analysis, decreased RA risk was also found in both breastfeeding 1-12 months (OR 0.783, 95% CI 0.641-0.957, p = 0.015) and breastfeeding > 12 months (OR 0.579, 95% CI 0.462-0.726, p < 0.0005). Sensitivity analysis and cumulative analysis further strengthened the validity of the results. No publication bias was found in this metaanalysis.
This metaanalysis suggests that breastfeeding is associated with a lower risk of RA, no matter if breastfeeding time is longer or shorter than 12 months.
既往研究探讨了母乳喂养与类风湿关节炎（RA）之间的关联，但其结果并不一致。本研究旨在进行一项荟萃分析，以阐明母乳喂养对RA风险的影响。
检索了PubMed、EMBASE、中国知网和万方数据库，查找截至2014年9月10日发表的相关研究。提取数据，并在随机效应模型中汇总多变量调整后的OR值及其95%可信区间。
荟萃分析共纳入6项研究（RA病例：1672例，样本量：143,670例）。总体而言，观察到母乳喂养与RA之间存在负相关（OR=0.675，95%可信区间为0.493-0.924，p=0.014）。在亚组分析中，母乳喂养1-12个月（OR=0.783，95%可信区间为0.641-0.957，p=0.015）和母乳喂养>12个月（OR=0.579，95%可信区间为0.462-0.726，p<0.0005）时，RA风险均降低。敏感性分析和累积分析进一步加强了结果的有效性。本荟萃分析未发现发表偏倚。
本荟萃分析表明，无论母乳喂养时间长于或短于12个月，母乳喂养均与较低的RA风险相关。
