Sochman J, Fabiían J, Englis M, Belán A
Vnitr Lek. 1989 Oct;35(10):1025-32.
The authors criticize contemporary views on creatine kinase kinetics in relation to the patency or occlusion of the coronary artery in the area of the infarction focus. In the investigation proper the time needed to achieve the peak plasma creatine kinase activity after the onset of infarction pain in patients with necroses in different areas of the left ventricle is assessed. Although the interpretation of the observed phenomenon is not clear so far, this finding makes the informative value of the hitherto used time parameter of the kinetics of this enzyme doubtful, in particular in thrombolytic treatment of myocardial infarction. In practice it is thus not possible to evaluate the restored patency of the artery to the necrotic focus on the basis of the above parameter.
作者批评了关于肌酸激酶动力学与梗死灶区域冠状动脉通畅或阻塞相关的当代观点。在实际研究中，评估了左心室不同区域发生坏死的患者在梗死性疼痛发作后达到血浆肌酸激酶活性峰值所需的时间。尽管目前对所观察到的现象的解释尚不清楚，但这一发现使迄今为止所使用的该酶动力学时间参数的信息价值受到质疑，尤其是在心肌梗死的溶栓治疗中。因此，在实践中不可能根据上述参数评估动脉至坏死灶的再通情况。
