2型糖尿病合并冠心病男性患者脂联素水平与血脂谱的关系
RELATIONSHIP OF ADIPONECTIN LEVEL WITH LIPID PROFILE IN TYPE-2 DIABETIC MEN WITH CORONARY HEART DISEASE.
作者信息
Durrani Sadaf, Shah Jasmin, Khan Mudassir Ahmad, Jan Muhammad Rasul
出版信息
J Ayub Med Coll Abbottabad. 2015 Jan-Mar;27(1):32-5.
BACKGROUND
Cerebro-vascular disease is a commonest long term complication of type-2 diabetes mellitus. The study was done to determine concentration of serum adiponectin and lipid profile in type-2 diabetic men with coronary heart disease (CHD) in the region of Khyber Pakhtunkhwa (KPK), and to find possible relationship between them.
METHODS
This was a cross-sectional study comprising of randomly selected thirty six healthy adult males and thirty six type-2 diabetic males with coronary heart disease. Their fasting blood samples were analysed for serum adiponectin, fasting blood glucose, glycosylated haemoglobin and lipid profile which included total cholesterol (T-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). The relationship of adiponectin with other variables in type-2 diabetic men with coronary heart disease was determined with Pearson correlations coefficient (r).
RESULTS
Type-2 diabetic males with coronary heart disease when compared to healthy males showed significantly low levels of serum adiponectin (p=<0.001) and HDL-C (p=<0.001) and significantly high level of FBG (p=<0.001), HbAlc (p=<0.001), TC (p=<0.05), TG (p=<0.05) and LDL-C (p=<0.05). Serum adiponectin level showed a significant negative correlation with FBG (r = -0.332; p= 0.04), HbAlc (r = -0.818; p=<0.01) and TG (r = -0.640; p=<0.01) in type-2 diabetic men with coronary heart disease. Adiponectin showed a significant positive association with HDL-C in controls (r = 0.948; p=<0.01) and patients of type-2 diabetes with CHD (r = 0.650; p=<0.01).
CONCLUSION
Serum adiponectin concentration is markedly decreased in patients of type-2 diabetes with coronary heart disease. Hypoadiponectinemia is related with deranged lipid profile, i.e., high TG and low HDL-C levels in type-2 diabetic men with CHD. Moreover, adiponectin is associated positively with HDL-C and negatively with HbAlc and TG levels in the studied population.
背景
脑血管疾病是2型糖尿病最常见的长期并发症。本研究旨在测定开伯尔-普赫图赫瓦省（KPK）地区患有冠心病（CHD）的2型糖尿病男性的血清脂联素浓度和血脂谱，并找出它们之间可能的关系。
方法
这是一项横断面研究，随机选取了36名健康成年男性和36名患有冠心病的2型糖尿病男性。对他们的空腹血样进行血清脂联素、空腹血糖、糖化血红蛋白和血脂谱分析，血脂谱包括总胆固醇（T-C）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。用Pearson相关系数（r）确定脂联素与患有冠心病的2型糖尿病男性其他变量之间的关系。
结果
与健康男性相比，患有冠心病的2型糖尿病男性血清脂联素（p=<0.001）和HDL-C（p=<0.001）水平显著降低，空腹血糖（FBG）（p=<0.001）、糖化血红蛋白（HbAlc）（p=<0.001）、总胆固醇（TC）（p=<0.05）、甘油三酯（TG）（p=<0.05）和低密度脂蛋白胆固醇（LDL-C）（p=<0.05）水平显著升高。在患有冠心病的2型糖尿病男性中，血清脂联素水平与空腹血糖（r = -0.332；p = 0.04）、糖化血红蛋白（r = -0.818；p=<0.01）和甘油三酯（r = -0.640；p=<0.01）呈显著负相关。在对照组（r = 0.948；p=<0.01）和患有冠心病的2型糖尿病患者中（r = 0.650；p=<0.01），脂联素与HDL-C呈显著正相关。
结论
患有冠心病的2型糖尿病患者血清脂联素浓度明显降低。低脂联素血症与血脂谱紊乱有关，即患有冠心病的2型糖尿病男性甘油三酯水平高和HDL-C水平低。此外，在所研究人群中，脂联素与HDL-C呈正相关，与HbAlc和甘油三酯水平呈负相关。
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