Marquardt Peter, Kaft Karin, Nieber Karen
Institut für Pharmazie, Universität Leipzig, Brüderstr. 34, 04193, Leipzig, Germany,
Wien Med Wochenschr. 2015 Jun;165(11-12):236-42. doi: 10.1007/s10354-015-0373-6. Epub 2015 Jul 17.
Herbal medicinal products have been used since several decades for the health care of children. Nevertheless, well-controlled clinical studies with herbal medicinal products for children are rare. The authors' objective therefore was to evaluate clinical trials with herbal medicinal products in children, based on a literature search in PubMed and Web of Science. A total of 133 trials were identified. 90 studies were randomized, 32.2% were randomized and double-blinded. Most studies were performed in China, in the age group 6-12 years, and in children with respiratory diseases, most often herbal medicinal products with Hedera helix were tested. The analysis revealed that studies on herbal medicinal products were feasible in children. Although clinical trials have been found, this literature search have limitations and did not cover all studies performed. However, only few clinical trials of high quality were identified. Further studies therefore are urgently needed to support the good empirical findings.
几十年来，草药产品一直用于儿童保健。然而，针对儿童的草药产品进行的严格对照临床试验却很少。因此，作者的目的是通过在PubMed和Web of Science上进行文献检索，评估针对儿童的草药产品的临床试验。共识别出133项试验。90项研究为随机试验，其中32.2%为随机双盲试验。大多数研究在中国进行，研究对象为6至12岁的儿童，且多为患有呼吸系统疾病的儿童，最常测试的草药产品是常春藤。分析表明，针对儿童的草药产品研究是可行的。虽然已发现临床试验，但此次文献检索存在局限性，并未涵盖所有开展的研究。然而，仅识别出少数高质量的临床试验。因此，迫切需要进一步的研究来支持良好的经验性发现。
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