Hofmann D, Hecker M, Völp A
Zentrum für Kinderheilkunde, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.
Phytomedicine. 2003 Mar;10(2-3):213-20. doi: 10.1078/094471103321659979.
To investigate if extracts from dried ivy leaves (Hedera helix L.) are effective in the treatment of chronic airway obstruction in children suffering from bronchial asthma.
Systematic review of trials documented in the literature with re-analysis of original data.
5 randomized controlled trials investigating the efficacy of ivy leaf extract preparations in chronic bronchitis, 3 of which were conducted in children and met our selection criteria. One compared ivy leaf extract cough drops to placebo, one compared suppositories to drops and one tested syrup against drops.
Body-plethysmographic and spirometric measures.
Drops were significantly superior to placebo in reducing airway resistance (primary outcome measure; p = 0.04 two-sided) and descriptively superior in all other 'objective' measures. For syrup and suppositories, at least 54%, resp. 35% of the effect against placebo were preserved.
The trials included in this review indicate that ivy leaf extract preparations have effects with respect to an improvement of respiratory functions of children with chronic bronchial asthma, but more far-reaching conclusions can hardly be drawn because of a meagre database, including the fact that only one primary trial included a placebo control. Further research, particularly into the long-term efficacy of the herbal extract, is needed.
研究常春藤叶（洋常春藤）提取物对患有支气管哮喘的儿童慢性气道阻塞是否有效。
对文献中记录的试验进行系统评价，并对原始数据进行重新分析。
5项随机对照试验研究了常春藤叶提取物制剂对慢性支气管炎的疗效，其中3项在儿童中进行，符合我们的入选标准。一项将常春藤叶提取物止咳滴剂与安慰剂进行比较，一项将栓剂与滴剂进行比较，一项将糖浆与滴剂进行测试。
体容积描记法和肺量计测量。
滴剂在降低气道阻力方面显著优于安慰剂（主要观察指标；双侧p = 0.04），在所有其他“客观”指标方面描述性地更优。对于糖浆和栓剂，至少分别保留了54%和35%的优于安慰剂的效果。
本综述纳入的试验表明，常春藤叶提取物制剂对改善慢性支气管哮喘儿童的呼吸功能有效果，但由于数据库有限，包括仅有一项主要试验纳入了安慰剂对照这一事实，难以得出更具深远意义的结论。需要进一步研究，特别是对该草药提取物的长期疗效进行研究。
