Kukoc M, Sapunar A, Vidjak V, Aras N, Grandić L, Radonić V, Matijević M
Acta Chir Iugosl. 1989;36 Suppl 2:495-9.
The authors describe the peripheral blood analyses in patients splenectomized for trauma in consideration on the concentration of the immunoglobulins total complement CH50 levels, T and B lymphocyte populations and compare this with the control group. The levels of the IgM were significantly decreased (p0.001) in splenectomised while the levels of the IgA and IgG were significantly increased (for IgA - p0.001, for IgG p0.01). Total lymphocyte count averaged 54501999 in splenectomized, with number of T cells 2463930 and B lymphocyte 460236. The control group showed total lymphocyte count 460236. The control group showed total lymphocyte count 520235 (p0.001) with number of T cells 314147 (p0.001) and number of B cells 7434 (p0.001), what is significantly less than in splenectomized population. The level of total complement CH50 in splenectomized population was 11216 (p0.01), what is significantly less than in the control group 12515. These data demonstrate persistent abnormalities in immune function and suggest a possible explantation for the increased rizu of sepsis in this group of patients.
作者描述了因创伤行脾切除术患者的外周血分析情况，涉及免疫球蛋白浓度、总补体CH50水平、T和B淋巴细胞群体，并将其与对照组进行比较。脾切除患者的IgM水平显著降低（p<0.001），而IgA和IgG水平显著升高（IgA - p<0.001，IgG - p<0.01）。脾切除患者的总淋巴细胞计数平均为5450±1999，T细胞数量为2463±930，B淋巴细胞数量为460±236。对照组的总淋巴细胞计数为5202±35（p<0.001），T细胞数量为3141±47（p<0.001），B细胞数量为743±4（p<0.001），均显著低于脾切除人群。脾切除人群的总补体CH50水平为112±16（p<0.01），显著低于对照组的125±15。这些数据表明免疫功能持续异常，并提示该组患者败血症风险增加的可能原因。
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