Schaefer Sara M, Gottschalk Christopher H, Jabbari Bahman
Department of Neurology, Yale University, 20 York St., New Haven, CT 06510, USA.
Toxins (Basel). 2015 Jul 14;7(7):2615-28. doi: 10.3390/toxins7072615.
Migraine is the most common neurological disorder, and contributes to disability and large healthcare costs in the United States and the world. The treatment of migraine until recently has focused on medications, both abortive and prophylactic, but treatment of chronic migraine has been revolutionized with the introduction of botulinum toxin injection therapy. In this review, we explore the current understanding of migraine pathophysiology, and the evolution of the use of botulinum toxin therapy including proposed pathophysiological mechanisms through animal data. We also discuss the similarities and differences between three injection techniques.
偏头痛是最常见的神经系统疾病，在美国乃至全球都导致了残疾和高昂的医疗费用。直到最近，偏头痛的治疗主要集中在药物治疗上，包括发作期治疗和预防性治疗，但随着肉毒杆菌毒素注射疗法的引入，慢性偏头痛的治疗发生了革命性变化。在这篇综述中，我们探讨了目前对偏头痛病理生理学的理解，以及肉毒杆菌毒素疗法的应用演变，包括通过动物数据提出的病理生理机制。我们还讨论了三种注射技术之间的异同。
Zotero 插件
