Rottenstreich Amihai, Revel-Vilk Shoshana, Bloom Allan I, Kalish Yosef
Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Department of Pediatric Hematology/Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Pediatr Blood Cancer. 2015 Nov;62(11):1974-8. doi: 10.1002/pbc.25641. Epub 2015 Jul 15.
Venous thromboembolism (VTE) is an increasingly recognized problem among children and adolescents. Although inferior vena cava (IVC) filter placement for pulmonary embolism prevention is well reported in adults, data regarding safety and efficacy in the pediatric age group are lacking.
At a large university hospital with a level I trauma center, medical records of children and adolescents who underwent IVC filter insertion were reviewed. Appropriateness of referral for retrieval was assessed in each case.
Fifty-nine children and adolescents (mean age 16 years) successfully underwent IVC filter insertion. All filters placed were retrievable. In 47 patients (79.7%), prophylactic filters were placed in the absence of acute VTE in the setting of trauma. In eight patients (13.5%), filters were placed due to contraindication to anticoagulation therapy with concomitant lower extremity deep vein thrombosis or pulmonary embolism. Filters were successfully retrieved in only 12 patients (20.3%), although an attempt at removal was appropriate and feasible in over 90% of cases. Mean duration of follow-up was 2.1 (range 0.4-7.3) years. A significantly higher retrieval rate was found in patients followed at our thrombosis clinic (P < 0.01). Ten patients (17%) experienced at least one filter-related complication.
Although in most cases, IVC filters were placed for prophylactic indications, the evidence to support their role in this setting is limited. Their low retrieval rate and high filter-related complication rate question their extensive utilization in children. Dedicated follow-up is necessary to detect complications and to ensure that an attempt at retrieval is made when feasible.
静脉血栓栓塞症(VTE)在儿童和青少年中是一个日益受到关注的问题。尽管下腔静脉(IVC)滤器置入预防肺栓塞在成人中有大量报道,但关于儿科年龄组安全性和有效性的数据却很缺乏。
在一家设有一级创伤中心的大型大学医院,对接受IVC滤器置入的儿童和青少年的病历进行了回顾。评估了每例患者取出滤器的转诊适宜性。
59名儿童和青少年(平均年龄16岁)成功接受了IVC滤器置入。所有置入的滤器均可取出。47例患者(79.7%)在创伤情况下无急性VTE时置入了预防性滤器。8例患者(13.5%)因抗凝治疗禁忌伴下肢深静脉血栓形成或肺栓塞而置入滤器。尽管在超过90%的病例中取出滤器的尝试是合适且可行的,但仅12例患者(20.3%)成功取出了滤器。平均随访时间为2.1年(范围0.4 - 7.3年)。在我们的血栓门诊随访的患者中取出率显著更高(P < 0.01)。10例患者(17%)经历了至少一种与滤器相关的并发症。
尽管在大多数情况下,IVC滤器是出于预防性目的置入的,但支持其在这种情况下作用的证据有限。其低取出率和高滤器相关并发症发生率质疑了它们在儿童中的广泛应用。需要进行专门的随访以检测并发症,并确保在可行时尝试取出滤器。