植物AGO蛋白的抗病毒作用
Antiviral roles of plant ARGONAUTES.
作者信息
Carbonell Alberto, Carrington James C
机构信息
Donald Danforth Plant Science Center, St. Louis, MO 63132, USA.
Donald Danforth Plant Science Center, St. Louis, MO 63132, USA.
出版信息
Curr Opin Plant Biol. 2015 Oct;27:111-7. doi: 10.1016/j.pbi.2015.06.013. Epub 2015 Jul 17.
Abstract
ARGONAUTES (AGOs) are the effector proteins functioning in eukaryotic RNA silencing pathways. AGOs associate with small RNAs and are programmed to target complementary RNA or DNA. Plant viruses induce a potent and specific antiviral RNA silencing host response in which AGOs play a central role. Antiviral AGOs associate with virus-derived small RNAs to repress complementary viral RNAs or DNAs, or with endogenous small RNAs to regulate host gene expression and promote antiviral defense. Here, we review recent progress towards understanding the roles of plant AGOs in antiviral defense. We also discuss the strategies that viruses have evolved to modulate, attenuate or suppress AGO antiviral functions.
摘要
AGO蛋白是在真核生物RNA沉默途径中发挥作用的效应蛋白。AGO蛋白与小RNA结合，并被编程靶向互补RNA或DNA。植物病毒会引发一种强大且特异的抗病毒RNA沉默宿主反应，其中AGO蛋白发挥核心作用。抗病毒AGO蛋白与病毒衍生的小RNA结合以抑制互补的病毒RNA或DNA，或与内源性小RNA结合以调节宿主基因表达并促进抗病毒防御。在此，我们综述了在理解植物AGO蛋白在抗病毒防御中作用方面的最新进展。我们还讨论了病毒为调节、减弱或抑制AGO蛋白抗病毒功能而进化出的策略。
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