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对伯格曼胶质细胞作为小脑回路功能调节因子的重新评估。

Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function.

作者信息

De Zeeuw Chris I, Hoogland Tycho M

机构信息

Cerebellar Coordination and Cognition, Netherlands Institute for Neuroscience Amsterdam, Netherlands ; Department of Neuroscience, Erasmus MC Rotterdam, Netherlands.

出版信息

Front Cell Neurosci. 2015 Jul 2;9:246. doi: 10.3389/fncel.2015.00246. eCollection 2015.

Abstract

Just as there is a huge morphological and functional diversity of neuron types specialized for specific aspects of information processing in the brain, astrocytes have equally distinct morphologies and functions that aid optimal functioning of the circuits in which they are embedded. One type of astrocyte, the Bergmann glial cell (BG) of the cerebellum, is a prime example of a highly diversified astrocyte type, the architecture of which is adapted to the cerebellar circuit and facilitates an impressive range of functions that optimize information processing in the adult brain. In this review we expand on the function of the BG in the cerebellum to highlight the importance of astrocytes not only in housekeeping functions, but also in contributing to plasticity and information processing in the cerebellum.

摘要

正如大脑中存在着大量专门用于特定信息处理方面的神经元类型,它们在形态和功能上具有多样性一样,星形胶质细胞也具有同样独特的形态和功能,有助于其所处神经回路的最佳运作。一种星形胶质细胞,即小脑的伯格曼胶质细胞(BG),是高度多样化星形胶质细胞类型的一个典型例子,其结构适应小脑回路,并促进一系列令人印象深刻的功能,从而优化成人大脑中的信息处理。在这篇综述中,我们详细阐述了BG在小脑中的功能,以突出星形胶质细胞不仅在维持基本功能方面,而且在促进小脑可塑性和信息处理方面的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e547/4488625/e9d96ff21674/fncel-09-00246-g0001.jpg

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