Cerminara Nadia L, Lang Eric J, Sillitoe Roy V, Apps Richard
School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA.
Nat Rev Neurosci. 2015 Feb;16(2):79-93. doi: 10.1038/nrn3886.
The adult mammalian cerebellar cortex is generally assumed to have a uniform cytoarchitecture. Differences in cerebellar function are thought to arise primarily through distinct patterns of input and output connectivity rather than as a result of variations in cortical microcircuitry. However, evidence from anatomical, physiological and genetic studies is increasingly challenging this orthodoxy, and there are now various lines of evidence indicating that the cerebellar cortex is not uniform. Here, we develop the hypothesis that regional differences in properties of cerebellar cortical microcircuits lead to important differences in information processing.
成年哺乳动物的小脑皮质通常被认为具有统一的细胞结构。人们认为，小脑功能的差异主要源于输入和输出连接的不同模式，而非皮质微电路的变化。然而，来自解剖学、生理学和遗传学研究的证据越来越多地挑战这一正统观念，现在有各种证据表明小脑皮质并非是统一的。在此，我们提出一个假说，即小脑皮质微电路特性的区域差异会导致信息处理方面的重要差异。
