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苯并喹啉胺 - 合成角型和线型二萘并[1,2-b:2',1'-e][1,4]二氮杂萘的关键中间体。

Benzoquinoline amines - Key intermediates for the synthesis of angular and linear dinaphthonaphthyridines.

机构信息

Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India.

出版信息

J Adv Res. 2015 Jul;6(4):631-41. doi: 10.1016/j.jare.2014.02.007. Epub 2014 Mar 5.

DOI:10.1016/j.jare.2014.02.007
PMID:26199754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4506974/
Abstract

A systematic study on the condensation reaction of 2,4-dichlorobenzo[h]quinoline and naphth-1-ylamine in the presence of CuI as catalyst to functionalised mono- and di-substituted (naphthalen-1-yl)benzo[h]quinoline amines was described. Subsequently these mono- and di-substituted amines on polyphosphoric acid catalysed cyclisation reaction with aromatic/heteroaromatic carboxylic acids led to the construction of angular and linear aromatic/heteroaromatic substituted dinaphthonaphthyridines in good yields.

摘要

本文系统研究了在 CuI 作为催化剂的条件下，2,4-二氯苯并[h]喹啉和萘-1-基胺的缩合反应，得到了功能化的单取代和二取代（萘-1-基）苯并[h]喹啉胺。随后，这些单取代和二取代胺在多聚磷酸催化下与芳香族/杂芳香族羧酸发生环化反应，得到了角状和线状的芳香族/杂芳香族取代的二萘并[1,2-b:2',1'-e][1,4]二氮杂萘，产率良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/4b1724f00d42/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/b816be736ba1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/4ebcb66a2906/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/4de418059f17/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/497182e2bad5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/30f63c14fff7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/4b1724f00d42/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/b816be736ba1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/4ebcb66a2906/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/4de418059f17/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/497182e2bad5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/30f63c14fff7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caca/4506974/4b1724f00d42/fx1.jpg

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本文引用的文献

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Eur J Med Chem. 2013;70:10-21. doi: 10.1016/j.ejmech.2013.06.060. Epub 2013 Aug 9.
2
cis-Dichloroplatinum(II) complexes tethered to dibenzo[c,h][1,6]naphthyridin-6-ones: synthesis and cytotoxicity in human cancer cell lines in vitro.顺式-二氯（二价铂）配合物连接到二苯并[c,h][1,6]萘啶-6-酮上：体外人癌细胞系中的合成和细胞毒性。
Eur J Med Chem. 2013 Nov;69:719-27. doi: 10.1016/j.ejmech.2013.09.037. Epub 2013 Sep 26.
3
Rational drug design based synthesis of novel arylquinolines as anti-tuberculosis agents.
基于理性药物设计的新型芳基喹啉类抗结核药物合成。
Bioorg Med Chem Lett. 2013 Nov 15;23(22):6097-105. doi: 10.1016/j.bmcl.2013.09.027. Epub 2013 Sep 16.
4
Synthesis, antibacterial and antioxidant activities of new 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromides.新型 1-烷基-4-(1-烷基-4-氧代-1,4-二氢喹啉-2-基)吡啶𬭩溴化物的合成、抗菌和抗氧化活性。
Eur J Med Chem. 2013 Nov;69:348-55. doi: 10.1016/j.ejmech.2013.08.050. Epub 2013 Sep 12.
5
In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles.一系列喹啉三唑类化合物的体外抗疟活性、β-血红素抑制作用及构效关系。
Eur J Med Chem. 2013 Nov;69:338-47. doi: 10.1016/j.ejmech.2013.08.046. Epub 2013 Sep 12.
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Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives.新型 2-氯-8-甲基喹啉胺衍生物的合成、抗抑郁和抗真菌评估。
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