miR-155-SOCS1 作为一个功能轴：满足证明的负担。
miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof.
机构信息
Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
Immunity. 2015 Jul 21;43(1):3-4. doi: 10.1016/j.immuni.2015.06.020.
PMID:26200005
Abstract
The importance of individual target genes for miRNA activity has been difficult to establish. In this issue of Immunity, Lu et al. (2015) disrupt the miR-155 binding site in the SOCS1 3' UTR in the mouse germline and show that this axis is important for T and NK cell function.
摘要
个体靶基因对于 miRNA 活性的重要性一直难以确定。在本期《免疫》杂志中，Lu 等人（2015 年）在小鼠生殖系中破坏了 SOCS1 3'UTR 中的 miR-155 结合位点，并表明该轴对于 T 和 NK 细胞功能很重要。
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