Candel Francisco Javier, Baos Elvira, Nieto Mercedes, Picazo Juan José
Francisco Javier Candel González, Department of Clinical Microbiology and Infectious Diseases Hospital Clínico San Carlos, Madrid, Spain.
Rev Esp Quimioter. 2015 Aug;28(4):214-6.
Coagulase negative Staphylococcus continues generating interest in critically ill patients, due to their infections in extended admissions, in instrumented patients and due to their described multidrug resistance, which include glycopeptide heterorresistance and the increase in oxazolidinone resistance. Ceftaroline is a new cephalosporin with activity against resistant gram-positives, which, being betalactam, may provide adequate safety profile in the critical ill patient. The aim of this study was to determine the activity of ceftaroline and other antimicrobial agents against methicillin and linezolid-resistant Staphylococcus epidermidis.
We studied susceptibility of ceftaroline, tigecycline, daptomycin and vancomycin in a total of sixty-eight methicillin and linezolid-resistant S. epidermidis isolates with clinical significance from an Intensive Care Unit, using E-test.
All strains were susceptible to the four antimicrobial agents, regardless of the level of resistance to linezolid.
Ceftaroline could be an alternative in the treatment of methicillin and linezolid-resistant S. epidermidis infections in critically ill patients.
凝固酶阴性葡萄球菌持续引起重症患者的关注，原因在于其在长期住院患者、使用器械患者中的感染，以及其所述的多重耐药性，包括糖肽类异质性耐药和恶唑烷酮耐药性增加。头孢洛林是一种新型头孢菌素，对耐药革兰氏阳性菌具有活性，作为β-内酰胺类药物，可能在重症患者中提供足够的安全性。本研究的目的是确定头孢洛林和其他抗菌药物对耐甲氧西林和耐利奈唑胺表皮葡萄球菌的活性。
我们使用E-test研究了来自重症监护病房的68株具有临床意义的耐甲氧西林和耐利奈唑胺表皮葡萄球菌分离株对头孢洛林、替加环素、达托霉素和万古霉素的敏感性。
所有菌株对这四种抗菌药物均敏感，无论对利奈唑胺的耐药水平如何。
头孢洛林可能是治疗重症患者耐甲氧西林和耐利奈唑胺表皮葡萄球菌感染的一种替代药物。
