在高架十字迷宫中，雌性Wistar大鼠探索行为的相对发光度。
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats.
作者信息
Sakae Diana Yae, Sakae Thiago Mamoru, Paschoalini Marta Aparecida, Faria Moacir Serralvo
机构信息
Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Departamento de Medicina, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil.
出版信息
Arq Neuropsiquiatr. 2015 Jul;73(7):601-6. doi: 10.1590/0004-282X20150088.
OBJECTIVE
This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).
METHODS
Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.
RESULTS
A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.
DISCUSSION
Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.
目的
本研究通过分析处于发情周期不同阶段的雌性Wistar大鼠在开放臂与封闭臂之间具有不同光照梯度（O/E∆Lux）的高架十字迷宫（EPM）中的探索行为，评估了两种EPM配置。
方法
给雌性Wistar大鼠注射咪达唑仑（MDZ，1.0 mg.kg-1），并在EPM 10 O/E∆Lux或EPM 96 O/E∆Lux中测试其探索行为。
结果
多元回归分析表明，O/E∆Lux与开放臂进入百分比和开放臂停留时间呈负相关，这表明随着O/E∆Lux增加，开放臂探索减少。发情周期阶段对两种EPM中的开放臂探索均无影响。在96 O/E∆Lux EPM中检测到MDZ诱导的抗焦虑作用在发情周期的所有阶段均存在。
讨论
本研究结果表明O/E∆Lux对于在EPM中建立臂偏好以及保持EPM的预测有效性具有重要意义。
Zotero 插件