Lee Kwang Hwi, Kim Suk Jung, Park Young Mi, Kim Woogyeong, Yoon Jung Hee, Song Jong Woon, Kim Seung Ho, Lim Yun-Jung, Baek Hye Jin, Kim Seon-Jeong, Lee Yedaun
Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, Busan, 612-896, Republic of Korea.
Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
J Clin Ultrasound. 2015 Nov-Dec;43(9):556-62. doi: 10.1002/jcu.22278. Epub 2015 Jul 21.
To investigate gray-scale and color Doppler sonographic (US) features of complex fibroadenoma (FA), according to the Breast Imaging-Reporting and Data System (BI-RADS) lexicon.
From 2010 through 2013, 586 women with FAs were seen; 101 (17%) of those lesions were diagnosed as complex FAs on percutaneous needle biopsy or surgery. Among the patients with complex FAs, 67 who had US examination results available were included in this study. In addition, the results from 98 women who had simple FAs were included as controls. US features were retrospectively analyzed by two breast radiologists in consensus for shape, margin, echogenicity, posterior acoustic pattern, boundary, orientation, and associated findings. They also reassessed the BI-RADS category for FAs. Color Doppler US examination results were classified according to the amount of vascularity as absent, moderate, or marked.
Complex FA were larger than simple FAs were (14.5 cm versus 12.1 cm, p > 0.05). On univariate analysis, a round to irregular shape, an uncircumscribed margin, the presence of associated findings, and BI-RADS categorization as 4a and 4b were more frequently revealed in complex than in simple FAs (p < 0.05). Multivariate analysis revealed that the tumor margin was a predictive factor for complex FA (odds ratio: 6.08; 95% confidence interval: 1.14-32.49, p < 0.05). On color Doppler US, the complex FAs had higher degrees of vascularity than simple FA (p < 0.05).
Complex FAs, in comparison with simple FAs, tend to have more aggressive features and to be in higher BI-RADS categories on US examination.
根据乳腺影像报告和数据系统（BI-RADS）词典，研究复杂纤维腺瘤（FA）的灰阶及彩色多普勒超声（US）特征。
2010年至2013年期间，共诊治586例患有纤维腺瘤的女性；其中101例（17%）病变经皮穿刺活检或手术诊断为复杂纤维腺瘤。在患有复杂纤维腺瘤的患者中，67例有超声检查结果，纳入本研究。此外，98例患有单纯纤维腺瘤的女性的检查结果作为对照。由两位乳腺放射科医生对超声特征进行回顾性分析，就形态、边缘、回声性、后方声像、边界、方向及相关表现达成共识。他们还重新评估了纤维腺瘤的BI-RADS分类。彩色多普勒超声检查结果根据血管数量分为无、中等或丰富。
复杂纤维腺瘤比单纯纤维腺瘤大（14.5 cm对12. cm，p>0.05）。单因素分析显示，复杂纤维腺瘤比单纯纤维腺瘤更常表现为圆形至不规则形、边界不清、存在相关表现以及BI-RADS分类为4a和4b（p<0.05）。多因素分析显示，肿瘤边缘是复杂纤维腺瘤的预测因素（比值比：6.08；95%置信区间：1.14 - 32.49，p<0.05）。彩色多普勒超声检查显示，复杂纤维腺瘤的血管程度高于单纯纤维腺瘤（p<0.05）。
与单纯纤维腺瘤相比，复杂纤维腺瘤在超声检查中往往具有更具侵袭性的特征，且BI-RADS分类更高。
