Çakar Mustafa, Balta Şevket, Şarlak Hakan, Akhan Muharrem, Demirkol Sait, Karaman Murat, Ay Seyit Ahmet, Kurt Ömer, Çayci Tuncer, İnal Satılmış, Demirbaş Şeref
Internal Medicine, Eskişehir Military Hospital, Eskişehir, Turkey.
Cardiology, Eskişehir Military Hospital, Eskişehir, Turkey.
Arch Endocrinol Metab. 2015 Oct;59(5):407-13. doi: 10.1590/2359-3997000000061. Epub 2015 Jul 21.
There is a growing body of data supporting the association between diabetes and microcirculatory disfunction. We aimed to study e-selectin levels, and their associations with serum markers of inflammation and arterial stiffness in prediabetes and newly diagnosed diabetes patients in this study.
Sixty patients (25 females) with a newly established elevated fasting serum glucose [20 impaired fasting glucose (IFG), 20 impaired glucose tolerance (IGT), 20 newly diagnosed diabetes (T2DM)] and 17 healthy controls (13 females) were included in the study. Serum e-selectin and hs-CRP levels, and arterial stiffness parameters of the patients were studied.
Fasting serum glucose was the most important predictor of serum e-selectin levels. Pulse wave velocity and central aortic pressures were significantly higher in IFG, IGT and T2DM groups, compared to controls (p = 0.001, < 0.001, 0.013 and 0.015, 0.002, 0.009, respectively). The mean arterial pressure did not show any significant association with serum e-selectin and hs-CRP levels (β coefficient: 0.092, p = 0.358; and β coefficient: 0.189, p = 0.362, respectively).
Prediabetes patients have increasing e-selectin levels through the diagnosis of T2DM. E-selectin is associated with serum glucose levels. Prediabetic and newly diagnosed diabetics have higher arterial stiffness measurements. Serum e-selectin may be a good marker of endothelial inflammation and dysfunction increasing in parallel with serum glucose levels, predicting future cardiovascular events.
越来越多的数据支持糖尿病与微循环功能障碍之间的关联。在本研究中，我们旨在研究糖尿病前期和新诊断糖尿病患者的E选择素水平及其与炎症血清标志物和动脉僵硬度的关联。
本研究纳入了60例患者（25例女性），其空腹血清葡萄糖水平新近升高[20例空腹血糖受损（IFG）、20例糖耐量受损（IGT）、20例新诊断糖尿病（T2DM）]，以及17例健康对照者（13例女性）。研究了患者的血清E选择素和hs-CRP水平以及动脉僵硬度参数。
空腹血清葡萄糖是血清E选择素水平的最重要预测因素。与对照组相比，IFG、IGT和T2DM组的脉搏波速度和中心主动脉压显著更高（p值分别为0.001、<0.001、0.013和0.015、0.002、0.009）。平均动脉压与血清E选择素和hs-CRP水平均无显著关联（β系数分别为0.092，p = 0.358；以及β系数为0.189，p = 0.362）。
从糖尿病前期到诊断为T2DM，患者的E选择素水平不断升高。E选择素与血清葡萄糖水平相关。糖尿病前期和新诊断的糖尿病患者的动脉僵硬度测量值更高。血清E选择素可能是内皮炎症和功能障碍的良好标志物，其与血清葡萄糖水平平行升高，可预测未来心血管事件。
