Hsu Ching-Sheng, Hsu Shih-Jer, Chen Hung-Chia, Liu Chen-Hua, Jeng Jenher, Liu Chun-Jen, Chen Pei-Jer, Chen Ding-Shinn, Kao Jia-Horng
Division of Gastroenterology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Hepatol Int. 2013 Mar;7(1):171-9. doi: 10.1007/s12072-012-9390-3. Epub 2012 Jul 8.
IL28B genotypes have a strong impact on treatment outcomes of chronic hepatitis C (CHC) and on-treatment viral kinetics. Since metabolic regulation and interferon response are highly integrated, metabolic profiles may play an important role in the link between IL28B genotypes and hepatitis C virus (HCV) infection. Thus, the association of IL28B rs8099917 genotypes with metabolic profiles and the impact of metabolic profiles on hepatitis C viral kinetic parameters were examined.
A case-control analysis including 278 CHC patients and 280 subjects without chronic HCV infection was performed. The associations of IL28B rs8099917 genotype with pretreatment metabolic profiles and early viral kinetic parameters were evaluated.
Compared to HCV genotype 1 patients, the differences in metabolic profiles were more significant in genotype 2 patients. HCV genotype 2 patients with TT genotype had higher serum total cholesterol and high density lipoprotein (HDL) levels than those with GT genotype, and the differences remained significant when adjusted for age, sex, and body mass index (p = 0.005 for total cholesterol; p = 0.006 for HDL). In addition, patients with higher serum TG, higher fasting blood glucose, and lower HDL had a lower viral clearance rate.
IL28B genotypes may affect lipid profiles of CHC patients, especially in HCV-genotype 2 patients. Patients with higher serum fasting blood glucose, triglyceride, and lower HDL have a lower viral clearance rate during pegylated interferon plus ribavirin therapy.
IL28B基因分型对慢性丙型肝炎（CHC）的治疗结果及治疗期间的病毒动力学有强烈影响。由于代谢调节与干扰素反应高度整合，代谢谱可能在IL28B基因分型与丙型肝炎病毒（HCV）感染之间的联系中发挥重要作用。因此，研究了IL28B rs8099917基因分型与代谢谱的关联以及代谢谱对丙型肝炎病毒动力学参数的影响。
进行了一项病例对照分析，纳入278例CHC患者和280例无慢性HCV感染的受试者。评估了IL28B rs8099917基因分型与治疗前代谢谱及早期病毒动力学参数的关联。
与HCV基因1型患者相比，基因2型患者的代谢谱差异更显著。TT基因型的HCV基因2型患者血清总胆固醇和高密度脂蛋白（HDL）水平高于GT基因型患者，在调整年龄、性别和体重指数后，差异仍显著（总胆固醇p = 0.005；HDL p = 0.006）。此外，血清甘油三酯（TG）较高、空腹血糖较高且HDL较低的患者病毒清除率较低。
IL28B基因分型可能影响CHC患者的血脂谱，尤其是在HCV基因2型患者中。在聚乙二醇干扰素联合利巴韦林治疗期间，空腹血糖、甘油三酯较高且HDL较低的患者病毒清除率较低。
