Zhang Wenbo, Xu Ying, Ma Gui, Qi Weidong, Gu Haiyong, Jiang Pengcheng
a 1 Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
b 2 Laboratory Center, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
J Invest Surg. 2015;28(6):346-53. doi: 10.3109/08941939.2015.1010024. Epub 2015 Jul 23.
Numerous studies have investigated the association between DNMT3A rs1550117 A>G polymorphism and cancer risk, but the results are inconsistent. To obtain a more precise evaluation of the relationship, we performed a meta-analysis of 10 case-control studies involving a total of 2184 cancer cases and 3420 controls. Our findings demonstrated a significant association between DNMT3A rs1550117 A>G polymorphism and increased risk of cancer in three genetic models: AA vs. AG + GG (OR, 1.79; 95% CI, 1.12-2.88; p = 0.015), AA vs. GG (OR, 1.81; 95% CI, 1.11-2.95; p = 0.018) and AA vs. AG (OR 1.77; 95% CI 1.13-2.79; p = 0.013). In a stratified analysis by cancer type, significant association between DNMT3A rs1550117 A>G polymorphism and increased risk of colorectal cancer was identified in four genetic models: AA vs. AG + GG (OR, 3.07; 95% CI, 1.56-6.06; p = 0.001), AA vs. GG (OR, 3.16; 95% CI, 1.58-6.29; p = 0.001), AA vs. AG (OR, 2.87; 95% CI, 1.41-5.84; p = 0.004), A vs. G (OR, 1.43; 95% CI, 1.11-1.83; p = 0.005). Furthermore, a stratified analysis by ethnicity, significant increased risk of cancer was found among Asians in three genetic models: AA vs. AG + GG (OR, 1.77; 95% CI, 1.09-2.88; p = 0.022), AA vs. GG (OR, 1.78; 95% CI, 1.08-2.96; p = 0.025), AA vs. AG (OR, 1.75; 95% CI, 1.10-2.79; p = 0.019). No significant publication bias was revealed for the meta-analysis. Sensitivity analysis suggested the reliability of our findings. In conclusion, this meta-analysis suggests that DNMT3A rs1550117 A>G polymorphism may be associated with cancer susceptibility.
众多研究探讨了DNA甲基转移酶3A（DNMT3A）基因rs1550117 A>G多态性与癌症风险之间的关联，但结果并不一致。为了更精确地评估二者关系，我们对10项病例对照研究进行了荟萃分析，这些研究共纳入2184例癌症病例和3420例对照。我们的研究结果表明，在三种遗传模型中，DNMT3A rs1550117 A>G多态性与癌症风险增加显著相关：AA与AG + GG相比（比值比[OR]，1.79；95%置信区间[CI]，1.12 - 2.88；p = 0.015），AA与GG相比（OR，1.81；95% CI，1.11 - 2.95；p = 0.018），以及AA与AG相比（OR 1.77；95% CI 1.13 - 2.79；p = 0.013）。在按癌症类型进行的分层分析中，在四种遗传模型中发现DNMT3A rs1550117 A>G多态性与结直肠癌风险增加显著相关：AA与AG + GG相比（OR，3.07；95% CI，1.56 - 6.06；p = 0.001），AA与GG相比（OR，3.16；95% CI，1.58 - 6.29；p = 0.001），AA与AG相比（OR，2.87；95% CI，1.41 - 5.84；p = 0.004），A与G相比（OR，1.43；95% CI，1.11 - 1.83；p = 0.005）。此外，在按种族进行的分层分析中，在三种遗传模型中发现亚洲人患癌症的风险显著增加：AA与AG + GG相比（OR，1.77；95% CI，1.09 - 2.88；p = 0.022），AA与GG相比（OR，1.78；95% CI，1.08 - 2.96；p = 0.025），AA与AG相比（OR，1.75；95% CI，1.10 - 2.79；p = 0.019）。荟萃分析未发现显著的发表偏倚。敏感性分析表明我们研究结果的可靠性。总之，这项荟萃分析表明DNMT3A rs1550117 A>G多态性可能与癌症易感性相关。
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