Jing Wu, Otsuka Toshimi, Nakamura Masakatsu, Sakurai Naoko, Takano Hikaru, Hayashi Tasuku, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Tahara Tomomitsu, Shibata Tomoyuki, Arisawa Tomiyasu
Department of Gastroenterology, Kanazawa Medical University, Uchinada-machi, Ishikawa 920-0293, Japan.
Department of Gastroenterology, Fujita Health University, Kutsukake-cho, Toyoake 470-1192, Japan.
Oncol Lett. 2019 Mar;17(3):3482-3488. doi: 10.3892/ol.2019.9948. Epub 2019 Jan 18.
The aim of the present study was to investigate whether single nucleotide polymorphisms in the gene are associated with susceptibility to gastric cancer in the Japanese population. The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy. Of 708 controls, 409 were classified into two groups histologically: 99 cases with and 310 cases without gastric mucosal atrophy. Overall, homozygosity for the rs6733868 minor allele was significantly associated with a reduced risk of gastric cancer (odds ratio [OR], 0.621; 95% confidence interval [CI], 0.402-0.958; P=0.031), especially of the intestinal type (OR, 0.494; 95% CI, 0.274-0.890; P=0.019). In subjects >60 years, rs6733868 minor allele homozygosity was significantly associated with gastric cancer susceptibility. Carriers of the rs6733868 minor allele had a reduced risk of severe gastric mucosal atrophy (OR, 0.495; 95% CI, 0.299-0.826; P=0.0069). In addition, the number of minor alleles of both rs6733868 and rs13428812 was significantly correlated with the risk of (HP) infection (P=0.0070 and P=0.0050, respectively). However, rs13428812 was not associated with severe gastric mucosal atrophy or gastric carcinogenesis. The present results suggest that polymorphisms serve roles in the progression from HP infection to gastric mucosal atrophy and gastric carcinogenesis in terms of degree and manner.
本研究的目的是调查该基因中的单核苷酸多态性是否与日本人群患胃癌的易感性相关。本病例对照研究检测了343例胃癌患者和708例经上消化道十二指肠内镜检查无胃恶性肿瘤的受试者中该基因的单核苷酸多态性（rs6733868和rs13428812）与癌症易感性之间的关联。在708名对照者中，409例根据组织学分为两组：99例有胃黏膜萎缩，310例无胃黏膜萎缩。总体而言，rs6733868次要等位基因的纯合性与胃癌风险降低显著相关（优势比[OR]，0.621；95%置信区间[CI]，0.402 - 0.958；P = 0.031），尤其是肠型胃癌（OR，0.494；95% CI，0.274 - 0.890；P = 0.019）。在60岁以上的受试者中，rs6733868次要等位基因纯合性与胃癌易感性显著相关。rs6733868次要等位基因携带者患严重胃黏膜萎缩的风险降低（OR，0.495；95% CI，0.299 - 0.826；P = 0.0069）。此外，rs6733868和rs13428812的次要等位基因数量均与幽门螺杆菌（HP）感染风险显著相关（分别为P = 0.0070和P = 0.0050）。然而，rs13428812与严重胃黏膜萎缩或胃癌发生无关。目前的结果表明，该基因多态性在从HP感染到胃黏膜萎缩和胃癌发生的进展过程中，在程度和方式方面发挥作用。
