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复发性角膜糜烂综合征中的上方角膜缘上皮病变

Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome.

作者信息

Rac Kathrin, Lee Graham A, Vincent Stephen J

机构信息

*City Eye Centre, Brisbane, Queensland, Australia; †University of Queensland, Brisbane, Queensland, Australia; and ‡School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

出版信息

Cornea. 2015 Sep;34(9):1110-3. doi: 10.1097/ICO.0000000000000545.

Abstract

PURPOSE

To highlight the finding of occult areas of poor epithelial adhesion in the superior perilimbal cornea in a minority of patients with recalcitrant recurrent corneal erosion syndrome presenting with corneal erosion elsewhere on the corneal surface.

PATIENT POPULATION

Thirty-one eyes of 31 consecutive patients with corneal erosion undergoing mechanical debridement of the epithelium before diamond burr keratectomy for recurrent corneal erosion.

METHODS

Thirty-one eyes of 31 consecutive patients with recurrent corneal erosion were examined for poor epithelial adhesion determined by mechanical debridement with a dry microsponge.

RESULTS

During debridement, 8 of 31 eyes (25.8%) displayed a large arcuate area of occult dysfunction of adhesion in the superior perilimbal area. None of these eyes showed recurrence over a mean of 18 months after diamond burr keratectomy (95% confidence interval, 0%-36.9%).

CONCLUSIONS

Mechanical debridement with a microsponge identified a significant minority of patients with poor adhesion in the superior perilimbal cornea away from the area of obvious erosion and increased the target area for diamond burr keratectomy. This 2-pronged approach allowed successful management of this group.

摘要

目的

强调在少数角膜表面其他部位出现角膜糜烂的顽固性复发性角膜糜烂综合征患者中,上方角膜缘角膜上皮黏附不佳的隐匿区域的发现。

患者群体

31例连续接受角膜糜烂治疗的患者的31只眼,在进行钻石磨盘角膜切除术治疗复发性角膜糜烂之前,先对上皮进行机械清创。

方法

对31例连续复发性角膜糜烂患者的31只眼进行检查,通过用干燥微海绵进行机械清创来确定上皮黏附不佳的情况。

结果

在清创过程中,31只眼中有8只(25.8%)在上方角膜缘区域显示出大片隐匿性黏附功能障碍的弧形区域。在钻石磨盘角膜切除术后平均18个月期间,这些眼中无一例复发(95%置信区间,0%-36.9%)。

结论

用微海绵进行机械清创发现,有相当一部分患者上方角膜缘角膜存在远离明显糜烂区域的黏附不佳情况,扩大了钻石磨盘角膜切除术的目标区域。这种双管齐下的方法成功地治疗了这组患者。

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