Akgoc Zeynep, Iosim Sonia, Seyfried Thomas N
Biology Department, Boston College, 140 Commonwealth Ave, MA, 02467, Chestnut Hill, USA,
Lipids. 2015 Sep;50(9):907-12. doi: 10.1007/s11745-015-4045-5. Epub 2015 Jul 24.
Bis(monoacylglycero)phosphate (BMP) is a structural isomer of phosphatidylglycerol (PtdGro) with an unusual sn-1:sn-1' fatty acyl configuration and is found almost exclusively in late endosomes/lysosomes. BMP comprises only about 1-2% of the total phospholipids in most mammalian cells, but accumulates in tissues of humans and animals with lysosomal storage disorders including the gangliosidoses. Total BMP content was significantly greater in cells of macrophage/microglial origin than in cells of macroglial origin. BMP composition was similar in tumorigenic/metastatic macrophages and non-tumorigenic macrophages/microglia. Finally, BMP fatty acid composition differed between cells grown in culture and obtained in vivo suggesting an influence from growth environment.
双（单酰甘油）磷酸酯（BMP）是磷脂酰甘油（PtdGro）的一种结构异构体，具有不寻常的sn-1:sn-1'脂肪酰基构型，几乎仅存在于晚期内体/溶酶体中。在大多数哺乳动物细胞中，BMP仅占总磷脂的约1-2%，但在患有包括神经节苷脂沉积症在内的溶酶体贮积症的人类和动物组织中会积累。巨噬细胞/小胶质细胞来源的细胞中的总BMP含量显著高于大胶质细胞来源的细胞。致瘤/转移性巨噬细胞与非致瘤性巨噬细胞/小胶质细胞中的BMP组成相似。最后，培养生长的细胞和体内获取的细胞之间的BMP脂肪酸组成不同，这表明生长环境会产生影响。
