Louie H W, Pang M, Lewis W, Drinkwater D C, Laks H
Curr Surg. 1989 Nov-Dec;46(6):479-83.
HHT was performed between minimally genetic mismatched inbred strains of rats. There was no evidence of rejection and immunosuppressive therapy was not instituted. Immunohistochemical analysis using peroxidase conjugated monoclonal anti-rat ASMA of cardiac arterioles in which AGAS developed revealed a decreased peroxidase signal. The data suggest that modulation of actin expression in subintimal cells of cardiac arterioles may play a critical role in the pathologic development of AGAS.
肝动脉-门静脉瘘（HHT）是在大鼠最小基因错配的近交系之间进行的。没有排斥反应的证据，也未进行免疫抑制治疗。对出现AGAS的心脏小动脉使用过氧化物酶偶联的抗大鼠平滑肌肌动蛋白（ASMA）单克隆抗体进行免疫组织化学分析，结果显示过氧化物酶信号减弱。数据表明，心脏小动脉内膜下细胞中肌动蛋白表达的调节可能在AGAS的病理发展中起关键作用。
