de Rezende Márcia Uchoa, Rosa Thiago Bittencourt Carvalho, Pasqualin Thiago, Frucchi Renato, Okazaki Erica, Villaça Paula Ribeiro
Department of Orthopedics and Traumatology, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Hematology Service, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Acta Ortop Bras. 2015 May-Jun;23(3):162-6. doi: 10.1590/1413-785220152302145885.
To assess whether joint lavage, viscosupplementation and triamcinolone improve joint pain, function and quality of life in patients with severe hemophilic arthropathy.
Fourteen patients with knee and/or ankle hemophilic arthritis with and without involvement of other joints underwent joint lavage and subsequent injection of hylan G-F20 and triamcinolone in all affected joints. The patients answered algo-functional questionnaires (Lequesne and WOMAC), visual analog scale for pain (VAS) and SF-36 preoperatively, and at one, three, six and twelve months postoperatively.
Sixteen knees, 15 ankles, 8 elbows and one shoulder were treated in 14 patients. Six patients had musculoskeletal bleeding [ankle (1), leg muscle (2) and knees (4)] at 3 months affecting the results. Pain did not improve significantly. Function improved (WOMAC p=0.02 and Lequesne p=0.01). The physical component of SF-36 improved at all time points except at 3 months, with best results at one-year follow-up (baseline = 33.4; 1 month = 39.6; 3 months= 37.6; 6 months 39.6 and 1 year = 44.6; p < 0.001).
Joint lavage followed by injection of triamcinolone and hylan G-F20 improves function and quality of life progressively up to a year, even in severe hemophilic arthropathy. Level of Evidence IV, Case Series.
评估关节灌洗、玻璃酸钠补充疗法和曲安奈德是否能改善重度血友病性关节病患者的关节疼痛、功能和生活质量。
14例患有膝关节和/或踝关节血友病性关节炎且有或无其他关节受累的患者,对所有受累关节进行关节灌洗,随后注射透明质酸钠凝胶G-F20和曲安奈德。患者在术前、术后1个月、3个月、6个月和12个月回答功能问卷(Lequesne和WOMAC)、疼痛视觉模拟量表(VAS)和SF-36问卷。
14例患者共治疗了16个膝关节、15个踝关节、8个肘关节和1个肩关节。6例患者在3个月时出现肌肉骨骼出血[踝关节(1例)、腿部肌肉(2例)和膝关节(4例)],影响了结果。疼痛改善不明显。功能有所改善(WOMAC p=0.02,Lequesne p=0.01)。除3个月外,SF-36的身体维度在所有时间点均有改善,在1年随访时效果最佳(基线=33.4;1个月=39.6;3个月=37.6;6个月=39.6;1年=44.6;p<0.001)。
即使是重度血友病性关节病,关节灌洗后注射曲安奈德和透明质酸钠凝胶G-F20也能在长达一年的时间里逐渐改善功能和生活质量。证据等级IV,病例系列。