Tanner Martin E
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Chem Biol. 2015 Jul 23;22(7):806-7. doi: 10.1016/j.chembiol.2015.07.003.
Pictet-Spenglerases catalyze key condensation/cyclization reactions between aromatic ethylamines and aldehydes in the biosynthesis of alkaloids. In this issue of Chemistry & Biology, Mori et al. (2015) report the structural elucidation of a novel type of Pictet-Spenglerase involved in the biosynthesis of the β-carboline alkaloids.
Pictet-Spengler酶催化生物碱生物合成过程中芳香族乙胺与醛之间的关键缩合/环化反应。在本期《化学生物学》中，森等人（2015年）报道了一种参与β-咔啉生物碱生物合成的新型Pictet-Spengler酶的结构解析。
