Wagner Clara, Abramson Lyn Y, Alloy Lauren B
VA Center for Health Equity Research and Promotion, Philadelphia VA Medical Center, 3900 Woodland Avenue, Building 4100 (Annex) Philadelphia PA 19104, USA.
University of Wisconsin-Madison, Department of Psychology, Philadelphia, PA 19104, USA.
J Adolesc. 2015 Oct;44:32-6. doi: 10.1016/j.adolescence.2015.06.005. Epub 2015 Jul 21.
Deficits in executive functions (EFs) have been documented among individuals with unipolar depression, but controversy exists as to whether such deficits are state-dependent or are trait markers that precede disorder onset. The present study examined whether maternal history of unipolar depression was associated with deficits in EFs in early adolescent offspring, a finding that would support a trait marker conceptualization of EF deficits. Participants were a diverse sample (N = 493) of adolescents and their mothers recruited through local schools. Measures included semi-structured diagnostic interviews of mother and adolescent, mother-report forms assessing demographic information, and tests of executive function. Hierarchical linear regression analyses were conducted to examine the association between maternal depression diagnosis and adolescent offspring performance on tests of EF. Maternal lifetime history of depression was not associated with offspring EF task performance. Findings are not consistent with the conceptualization of impaired executive functions as trait markers of unipolar depression.
单相抑郁症患者存在执行功能(EFs)缺陷,然而,这些缺陷是与状态相关还是在疾病发作之前就作为特质标记存在,目前仍存在争议。本研究调查了母亲的单相抑郁症病史是否与青春期早期后代的执行功能缺陷有关,这一发现将支持执行功能缺陷的特质标记概念。参与者是通过当地学校招募的青少年及其母亲的多样化样本(N = 493)。测量方法包括对母亲和青少年的半结构化诊断访谈、评估人口统计学信息的母亲报告表以及执行功能测试。进行分层线性回归分析以检验母亲抑郁症诊断与青少年后代执行功能测试表现之间的关联。母亲的终生抑郁症病史与后代执行功能任务表现无关。研究结果与将执行功能受损概念化为单相抑郁症特质标记的观点不一致。