Klimes-Dougan Bonnie, Ronsaville Donna, Wiggs Edythe A, Martinez Pedro E
Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55454, USA.
Biol Psychiatry. 2006 Nov 1;60(9):957-65. doi: 10.1016/j.biopsych.2006.03.031. Epub 2006 Aug 24.
Growing evidence demonstrates an association of neuropsychological deficits with mood disorders, but it is not yet clear whether these deficits are risk factors or are concomitant with the symptoms. This study examines the neuropsychological functioning of a group of adolescent offspring who are at risk for a mood disorder by virtue of being raised by mothers who have been diagnosed with major depressive disorder (MDD) or bipolar disorder (BPD).
Adolescent offspring of mothers with BPD (n = 43) or MDD (n = 72) and of psychiatrically well parents (n = 50) completed a battery of neuropsychological tests to assess executive functioning, memory, and attention.
Children of mothers with BPD showed deficits in executive functioning and selective deficits in spatial memory and attention, in comparison with children of well mothers. Deficits were not found for children of MDD mothers.
Knowledge of these neurocognitive processes could aid ultimately in determining whether neurocognitive deficits precede BPD, whether unique profiles are associated with various types of mood disorders, and who may benefit from interventions.
越来越多的证据表明神经心理缺陷与情绪障碍有关，但尚不清楚这些缺陷是风险因素还是与症状同时出现。本研究考察了一组青少年后代的神经心理功能，这些青少年因母亲被诊断为重度抑郁症（MDD）或双相情感障碍（BPD）而面临情绪障碍风险。
患有BPD（n = 43）或MDD（n = 72）的母亲以及精神健康的母亲（n = 50）的青少年后代完成了一系列神经心理测试，以评估执行功能、记忆和注意力。
与健康母亲的孩子相比，患有BPD的母亲的孩子在执行功能方面存在缺陷，在空间记忆和注意力方面存在选择性缺陷。MDD母亲的孩子未发现缺陷。
了解这些神经认知过程最终可能有助于确定神经认知缺陷是否先于BPD出现，独特的特征是否与各种类型的情绪障碍相关，以及谁可能从干预中受益。
