长链非编码RNA HOTAIR：染色质动力学和癌症的主要调节因子
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer.
作者信息
Bhan Arunoday, Mandal Subhrangsu S
机构信息
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States.
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019, United States.
出版信息
Biochim Biophys Acta. 2015 Aug;1856(1):151-64. doi: 10.1016/j.bbcan.2015.07.001. Epub 2015 Jul 21.
Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in various cellular and physiological processes such as in gene regulation, chromatin dynamics, cell differentiation, and development. NcRNAs are dysregulated in a variety of human disorders including cancers, neurological disorders, and immunological disorders. The mechanisms through which ncRNAs regulate various biological processes and human diseases still remain elusive. HOX antisense intergenic RNA (HOTAIR) is a recently discovered long non-coding RNA (lncRNA) that plays critical role in gene regulation and chromatin dynamics, appears to be misregulated in a variety of cancers. HOTAIR interacts with key epigenetic regulators such as histone methyltransferase PRC2 and histone demethylase LSD1 and regulates gene silencing. Here, we have reviewed recent advancements in understanding the functions and regulation of HOTAIR and its association with cancer and other diseases.
非编码RNA（ncRNAs）是新兴的一类调控RNA，在各种细胞和生理过程中发挥关键作用，如基因调控、染色质动态变化、细胞分化和发育。ncRNAs在包括癌症、神经疾病和免疫疾病在内的多种人类疾病中表达失调。ncRNAs调控各种生物学过程和人类疾病的机制仍然不清楚。HOX反义基因间RNA（HOTAIR）是最近发现的一种长链非编码RNA（lncRNA），在基因调控和染色质动态变化中起关键作用，在多种癌症中似乎表达失调。HOTAIR与关键的表观遗传调控因子如组蛋白甲基转移酶PRC2和组蛋白去甲基化酶LSD1相互作用并调控基因沉默。在此，我们综述了在理解HOTAIR的功能、调控及其与癌症和其他疾病的关联方面的最新进展。
Zotero 插件