青少年和青年纳入癌症临床试验。
Inclusion of Adolescents and Young Adults in Cancer Clinical Trials.
作者信息
Weiss Aaron R, Hayes-Lattin Brandon, Kutny Matthew A, Stock Wendy, Stegenga Kristin, Freyer David R
出版信息
Semin Oncol Nurs. 2015 Aug;31(3):197-205. doi: 10.1016/j.soncn.2015.05.001. Epub 2015 May 7.
Abstract
OBJECTIVES
To discuss recent and current initiatives to increase enrollment of adolescents and young adult (AYA) cancer patients onto National Cancer Institute-funded clinical trials to improve outcomes.
DATA SOURCES
Peer-reviewed publications, websites of professional organizations.
CONCLUSION
Despite many challenges facing AYAs, recent studies illustrate that AYA-focused cancer clinical trials can be successfully developed and conducted. Development of the National Cancer Institute National Clinical Trials Network and related AYA-focused initiatives create new opportunities to expand clinical trials that serve AYAs.
IMPLICATIONS FOR NURSING PRACTICE
Nurses can influence AYA outcomes by leveraging their roles as educators and collaborators to increase participation in cancer clinical trials.
摘要
目标
探讨近期及当前为增加青少年和青年癌症患者参与美国国立癌症研究所资助的临床试验以改善治疗结果所采取的举措。
数据来源
同行评审出版物、专业组织网站。
结论
尽管青少年和青年面临诸多挑战，但近期研究表明，以青少年和青年为重点的癌症临床试验能够成功开展。美国国立癌症研究所国家临床试验网络的发展及相关以青少年和青年为重点的举措为扩大服务于青少年和青年的临床试验创造了新机会。
对护理实践的启示
护士可通过发挥教育者和协作者的作用来提高癌症临床试验的参与度，从而影响青少年和青年的治疗结果。
相似文献
1
Inclusion of Adolescents and Young Adults in Cancer Clinical Trials.
Semin Oncol Nurs. 2015 Aug;31(3):197-205. doi: 10.1016/j.soncn.2015.05.001. Epub 2015 May 7.
2
Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era.
Cancer Med. 2020 Mar;9(6):2146-2152. doi: 10.1002/cam4.2891. Epub 2020 Feb 3.
3
Patterns of National Cancer Institute-Sponsored Clinical Trial Enrollment in Black Adolescents and Young Adults.
Cancer Med. 2021 Nov;10(21):7620-7628. doi: 10.1002/cam4.4292. Epub 2021 Sep 30.
4
Case-linked analysis of clinical trial enrollment among adolescents and young adults at a National Cancer Institute-designated comprehensive cancer center.
Cancer. 2015 Dec 15;121(24):4398-406. doi: 10.1002/cncr.29669. Epub 2015 Sep 22.
5
Adolescent and young adult enrollment to a National Cancer Institute-sponsored National Clinical Trials Network Research Group over 25 years.
Cancer. 2021 Dec 15;127(24):4574-4584. doi: 10.1002/cncr.33855. Epub 2021 Aug 5.
6
Barriers and Facilitators to Adolescent and Young Adult Cancer Trial Enrollment: NCORP Site Perspectives.
JNCI Cancer Spectr. 2021 Mar 22;5(3). doi: 10.1093/jncics/pkab027. eCollection 2021 Jun.
7
Enrollment of adolescent and young adult patients newly diagnosed with cancer in NCI CTEP-sponsored clinical trials before and after launch of the NCI National Clinical Trials Network.
Cancer. 2022 Nov 1;128(21):3843-3849. doi: 10.1002/cncr.34402. Epub 2022 Sep 12.
8
Increased clinical trial enrollment among adolescent and young adult cancer patients between 2006 and 2012-2013 in the United States.
Pediatr Blood Cancer. 2019 Jan;66(1):e27426. doi: 10.1002/pbc.27426. Epub 2018 Sep 6.
9
Clinical research participation among adolescent and young adults at an NCI-designated Comprehensive Cancer Center and affiliated pediatric hospital.
Support Care Cancer. 2017 May;25(5):1579-1586. doi: 10.1007/s00520-016-3558-7. Epub 2017 Jan 10.
10
Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program.
J Oncol Pract. 2016 Apr;12(4):e388-95. doi: 10.1200/JOP.2015.009084. Epub 2016 Mar 29.
引用本文的文献
1
Survival of Adolescents and Young Adults with Prevalent Poor-Prognosis Metastatic Cancers: A Population-Based Study of Contemporary Patterns and Their Implications.
Cancer Epidemiol Biomarkers Prev. 2022 Apr 1;31(4):900-908. doi: 10.1158/1055-9965.EPI-21-0913.
2
Systems-Level Change to Alleviate Barriers to Cancer Clinical Trial Access for Adolescents and Young Adults in Australia.
J Adolesc Young Adult Oncol. 2022 Apr;11(2):173-180. doi: 10.1089/jayao.2021.0026. Epub 2021 Jul 22.
3
Health Insurance Payer Type and Ethnicity Are Associated with Cancer Clinical Trial Enrollment Among Adolescents and Young Adults.
J Adolesc Young Adult Oncol. 2022 Feb;11(1):104-110. doi: 10.1089/jayao.2021.0008. Epub 2021 May 19.
4
The HIV drug optimization agenda: promoting standards for earlier investigation and approvals of antiretroviral drugs for use in adolescents living with HIV.
J Int AIDS Soc. 2020 Sep;23 Suppl 5(Suppl 5):e25576. doi: 10.1002/jia2.25576.
5
Cost-effectiveness of Anti-CD19 chimeric antigen receptor T-Cell therapy in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia. A societal view.
Eur J Haematol. 2020 Aug;105(2):203-215. doi: 10.1111/ejh.13427. Epub 2020 May 4.
6
Systematic review of barriers and facilitators to clinical trial enrollment among adolescents and young adults with cancer: Identifying opportunities for intervention.
Cancer. 2020 Mar 1;126(5):949-957. doi: 10.1002/cncr.32675. Epub 2019 Dec 23.
7
Emerging Cancer Survival Trends, Disparities, and Priorities in Adolescents and Young Adults: A California Cancer Registry-Based Study.
JNCI Cancer Spectr. 2019 Jun;3(2):pkz031. doi: 10.1093/jncics/pkz031. Epub 2019 Jun 12.
8
Improving recruitment and retention of adolescents and young adults with cancer in randomized controlled clinical trials.
Int J Adolesc Med Health. 2019 Apr 11;33(4):/j/ijamh.ahead-of-print/ijamh-2018-0215/ijamh-2018-0215.xml. doi: 10.1515/ijamh-2018-0215.
9
Adolescent angst: enrollment on clinical trials.
Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):154-160. doi: 10.1182/asheducation-2018.1.154.
10
Sink or Collaborate: How the Immersive Model Has Helped Address Typical Adolescent and Young Adult Barriers at a Single Institution and Kept the Adolescent and Young Adult Program Afloat.
J Adolesc Young Adult Oncol. 2017 Dec;6(4):503-511. doi: 10.1089/jayao.2017.0051. Epub 2017 Aug 4.
本文引用的文献
1
Cancer statistics, 2014.
CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29. doi: 10.3322/caac.21208. Epub 2014 Jan 7.
2
Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children's Oncology Group.
Cancer. 2013 Dec 1;119(23):4162-9. doi: 10.1002/cncr.28342. Epub 2013 Sep 19.
3
Neuroblastoma in older children, adolescents and young adults: a report from the International Neuroblastoma Risk Group project.
Pediatr Blood Cancer. 2014 Apr;61(4):627-35. doi: 10.1002/pbc.24777. Epub 2013 Sep 13.
4
Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report.
J Clin Oncol. 2013 Aug 20;31(24):3034-43. doi: 10.1200/JCO.2012.47.0914. Epub 2013 Jul 15.
5
Young adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen do not need a bone marrow transplant in first remission.
Blood. 2013 Jun 27;121(26):5253-5. doi: 10.1182/blood-2013-03-484592.
6
Children's Oncology Group's 2013 blueprint for research: adolescent and young adult oncology.
Pediatr Blood Cancer. 2013 Jun;60(6):1055-8. doi: 10.1002/pbc.24431. Epub 2012 Dec 19.
7
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
J Clin Oncol. 2012 Nov 20;30(33):4148-54. doi: 10.1200/JCO.2011.41.5703. Epub 2012 Oct 22.
8
Acute lymphoblastic leukemia in young adults: which treatment?
Curr Opin Oncol. 2012 Sep;24(5):487-94. doi: 10.1097/CCO.0b013e32835538f8.
9
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial.
Lancet. 2012 May 19;379(9829):1879-86. doi: 10.1016/S0140-6736(12)60651-5. Epub 2012 May 16.
10
Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group.
J Clin Oncol. 2012 Jun 10;30(17):2094-101. doi: 10.1200/JCO.2011.38.9924. Epub 2012 May 7.
Zotero 插件