Docherty Sharron L, Crane Stacey, Haase Joan E, Robb Sheri L
Duke University, School of Nursing, 307 Trent Drive, DUMC 3322, Durham, NC 27710, USA, Phone: (+919) 668-3836.
Indiana University, School of Nursing, Indianapolis, IN, USA.
Int J Adolesc Med Health. 2019 Apr 11;33(4):/j/ijamh.ahead-of-print/ijamh-2018-0215/ijamh-2018-0215.xml. doi: 10.1515/ijamh-2018-0215.
Participation of adolescents and young adults (AYAs) with cancer in randomized clinical trials (RCTs) is necessary to advance treatments and psychosocial programs. Exploring AYAs experiences in an RCT will inform strategies to support recruitment and retention. A qualitative design was used to study the experiences of 13 AYAs in the Stories and Music for Adolescent and Young Adult Resilience during Transplant I (SMART I) trial. Key themes included: Weighing the Pros and Cons; Randomization Preferences; Completing Measures; and Worthwhile Experience. The experiences of AYAs during RCTs can bring insights that inform the design and management of AYA trials. Strategies include improving assent/consent processes, design of electronic interfaces and encouraging researcher flexibility.
癌症青少年和青年(AYA)参与随机临床试验(RCT)对于推进治疗和心理社会项目很有必要。探究AYA在RCT中的经历将为支持招募和留住参与者的策略提供信息。采用定性设计来研究13名AYA在移植I期青少年和青年恢复力的故事与音乐(SMART I)试验中的经历。关键主题包括:权衡利弊;随机化偏好;完成测量;以及有价值的经历。AYA在RCT期间的经历可以带来一些见解,为AYA试验的设计和管理提供参考。策略包括改进同意/知情同意程序、电子界面设计以及鼓励研究人员保持灵活性。