Kovács L Gábor, Nyolczas Noémi, Habon Tamás, Sepp Róbert, Piroth Zsolt, Hajas Ágota, Boncz Imre, Tomcsányi János, Kappelmayer János, Merkely Béla
Laboratóriumi Medicina Intézet, Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Pécs, Ifjúság útja 20., 7624.
Orv Hetil. 2015 Aug 2;156(31):1235-45. doi: 10.1556/650.2015.30219.
Cardiac natriuretic peptides (BNP, NT-proBNP) play a pivotal role in cardiovascular homeostasis, mainly due to their roles in vasodilatation, natriuresis, diuresis and due to their antiproliferative properties. Proper measurement of the natriuretic peptide levels may help differentiate between respiratory and cardiac forms of dyspnea, diagnose early forms of heart failure, evaluate severity of heart failure (prognosis) and monitor the efficacy of therapy. In many countries natriuretic peptide levels are being used as one of the earliest diagnostics tools to evaluate the involvement of the heart. Current theoretical and clinical data confirm the importance of natriuretic peptides in routine healthcare. These roles are clearly described in international recommendations and guidelines. In the current review the authors discuss the problems of the measurement of natriuretic peptides in Hungary, including several aspects related to laboratory medicine, cardiology and health economy.
心脏利钠肽（BNP、NT-proBNP）在心血管稳态中起关键作用，主要因其在血管舒张、利钠、利尿方面的作用以及其抗增殖特性。准确测量利钠肽水平有助于鉴别呼吸困难的呼吸性和心脏性病因，诊断早期心力衰竭，评估心力衰竭的严重程度（预后）并监测治疗效果。在许多国家，利钠肽水平被用作评估心脏受累情况的最早诊断工具之一。当前的理论和临床数据证实了利钠肽在日常医疗保健中的重要性。这些作用在国际建议和指南中得到了明确描述。在本综述中，作者讨论了匈牙利利钠肽测量方面的问题，包括与检验医学、心脏病学和卫生经济学相关的几个方面。
