Nand N, Mohan R, Khosla S N, Kumar P
J Assoc Physicians India. 1989 Aug;37(8):508-10.
Autonomic functions were studied in 30 adult cases of chronic severe anaemia (CSA) and equal number of age and sex matched healthy controls. Blood pressure and heart rate responses to standing, to respiration (expiratory-inspiratory ratio), to Valsalva manoeuvre (Valsalva ratio) and to hand immersion in ice cold water and given 1.8 mg of atropine intravenously were studied. Patients with CSA had significantly high basal pulse rate and low blood pressure as compared to control subjects (p less than 0.001). The expiratory inspiratory ratio was abnormal in 30% of the cases of CSA (p greater than 0.10) valsalva ratio was abnormal in 50% of cases (p less than 0.01) and postural tachycardia was observed in 60% of cases (p less than 0.001). Normal response to hand immersion in ice cold water was observed in 56.6% of cases (p less than 0.001). Atropine resulted in tachycardia in 73.4% of cases of CSA as compared to 86.7% of controls (p less than 0.10). All the cases of CSA showed one or more abnormal response and in 16.6% of cases all responses were abnormal.
对30例成年慢性重度贫血（CSA）患者以及同等数量年龄和性别匹配的健康对照者的自主神经功能进行了研究。研究了他们在站立、呼吸（呼气与吸气比率）、瓦尔萨尔瓦动作（瓦尔萨尔瓦比率）、手浸入冰冷水中以及静脉注射1.8毫克阿托品时的血压和心率反应。与对照受试者相比，CSA患者的基础脉搏率显著较高，血压较低（p<0.001）。30%的CSA病例呼气与吸气比率异常（p>0.10），50%的病例瓦尔萨尔瓦比率异常（p<0.01），60%的病例出现体位性心动过速（p<0.001）。56.6%的病例对手浸入冰冷水中的反应正常（p<0.001）。与86.7%的对照者相比，73.4%的CSA病例使用阿托品后出现心动过速（p<0.10）。所有CSA病例均表现出一种或多种异常反应，16.6%的病例所有反应均异常。
