急性呼吸窘迫综合征的结局与体重指数及糖尿病的关系。
The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus.
作者信息
Soubani Ayman O, Chen Wei, Jang Hyejeong
机构信息
Section of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
Department of Oncology, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, MI, USA.
出版信息
Heart Lung. 2015 Sep-Oct;44(5):441-7. doi: 10.1016/j.hrtlng.2015.06.007. Epub 2015 Jul 23.
OBJECTIVE
To determine the 28 day mortality of patients with ARDS in relation to body mass index (BMI) and presence diabetes mellitus (DM).
DESIGN
Retrospective cohort study of patients enrolled in the ARDS Network randomized controlled trials.
RESULTS
2914 patients were enrolled in these trials. 112 patients were underweight (BMI < 18.5), 948 patients were normal range (18.5 ≤ BMI < 25.0), 801 patients were overweight (25.0 ≤ BMI < 30.0), 687 patients were obese (30.0 ≤ BMI < 40.0), and 175 patients were severely obese (BMI ≥ 40.0). 469 patients had DM. There was no significant difference in the 28 day mortality in relation to BMI or presence of DM (underweight adjusted OR, 1.217; 95% CI, 0.749-1.979; overweight adjusted OR, 0.887; 95% CI, 0.696-1.131; obese adjusted OR, 0.812; 95% CI, 0.624-1.056; severely obese adjusted OR, 1.102; 95% CI, 0.716-1.695; and DM adjusted OR, 0.938; 95% CI, 0.728-1.208).
CONCLUSIONS
The short term mortality in patients with ARDS is not affected by BMI or the presence of DM.
目的
确定急性呼吸窘迫综合征（ARDS）患者28天死亡率与体重指数（BMI）及糖尿病（DM）的关系。
设计
对参与ARDS网络随机对照试验的患者进行回顾性队列研究。
结果
共有2914例患者参与了这些试验。112例患者体重过轻（BMI<18.5），948例患者体重在正常范围（18.5≤BMI<25.0），801例患者超重（25.0≤BMI<30.0），687例患者肥胖（30.0≤BMI<40.0），175例患者重度肥胖（BMI≥40.0）。469例患者患有糖尿病。BMI或糖尿病与28天死亡率之间无显著差异（体重过轻校正比值比为1.217；95%可信区间为0.749-1.979；超重校正比值比为0.887；95%可信区间为0.696-1.131；肥胖校正比值比为0.812；95%可信区间为0.624-1.056；重度肥胖校正比值比为1.102；95%可信区间为0.716-1.695；糖尿病校正比值比为0.938；95%可信区间为0.728-1.208）。
结论
ARDS患者的短期死亡率不受BMI或糖尿病的影响。
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