Colleti Junior Jose, Carla Armelin Benites Eliana, Spadaccia Dos Santos Fernandes Gustavo, Antonio Freddi Norberto, Koga Walter, Brunow de Carvalho Werther
Pediatric Intensive Care Unit, Santa Catarina Hospital , São Paulo, 01310 000, Brazil.
Pediatric Oncology Group, Santa Catarina Hospital , São Paulo, 01310 000, Brazil.
F1000Res. 2015 May 11;4:111. doi: 10.12688/f1000research.6393.1. eCollection 2015.
Severe hypercalcemia is a rare metabolic disorder in pediatric medicine. This report describes a rare case of severe hypercalcemia and its clinical manifestations in a 2-year-old toddler. The radiological findings caused by hypercalcemia and osteolysis were emblematic of the osteolytic lesions. Hypercalcemia led to massive pulmonary alveolar calcification. The hypercalcemia was successfully treated with pamidronate, a bisphosphonate drug class. Further investigation resulted in a diagnosis of acute lymphoblastic leukemia (ALL). The patient is currently on chemotherapy and has a favorable prognosis. Although severe hypercalcemia alone is an unusual finding as the first sign for ALL, this should be considered, not to mention the radiological images resulted from calcium deposits.
严重高钙血症是儿科学中一种罕见的代谢紊乱疾病。本报告描述了一例2岁幼儿严重高钙血症的罕见病例及其临床表现。高钙血症和骨质溶解引起的放射学表现是溶骨性病变的典型特征。高钙血症导致大量肺泡钙化。高钙血症通过使用双膦酸盐类药物帕米膦酸成功得到治疗。进一步检查确诊为急性淋巴细胞白血病(ALL)。该患者目前正在接受化疗,预后良好。尽管单独出现严重高钙血症作为ALL的首发症状并不常见,但仍应予以考虑,更不用说钙沉积导致的放射学影像了。