Jung Jae Hyun, Song Gwan Gyu, Lee Young Ho
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.
Immunol Invest. 2015;44(6):553-65. doi: 10.3109/08820139.2015.1043670. Epub 2015 Jul 27.
This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.
A meta-analysis was conducted of the associations between the IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and vasculitis.
A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegener's granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcet's disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10(-9)). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10(-9)). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035).
This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.
本研究旨在确定白细胞介素 -10（IL-10）基因多态性是否与血管炎易感性相关。
对IL-10 -1082 G/A、-819 C/T和-592 C/A基因多态性以及IL-10 -1082 G/A、-819 C/T、-592 C/A基因多态性单倍型与血管炎之间的关联进行荟萃分析。
荟萃分析共纳入21项比较研究，涉及4121例患者和5504例对照。荟萃分析显示，在所有研究对象中，IL-10 -1082 G等位基因与血管炎无关联（OR = 0.927，95% CI = 0.780 - 1.102，p = 0.389）。然而，疾病特异性荟萃分析显示，韦格纳肉芽肿（WG）与IL-10 -1082 G等位基因存在关联（OR = 0.729，95% CI = 0.547 - 0.971，p = 0.031）。荟萃分析显示，在所有研究对象中，血管炎与IL-10 -819 C等位基因存在关联（OR = 0.804，95% CI = 0.706 - 0.916，p = 0.001），在白塞病（BD）中也存在关联（OR = 0.724，95% CI = 0.679 - 0.781，p < 1.0×10(-9)）。对IL-10 -592 C等位基因的荟萃分析显示，在所有研究对象中其与血管炎存在关联（OR = 0.805，95% CI = 0.619 - 0.938，p = 0.005），在BD中也存在关联（OR = 0.718，95% CI = 0.661 - 0.781，p < 1.0×10(-9)）。对IL-10单倍型的荟萃分析显示，在欧洲人中，GCC单倍型与血管炎存在关联（OR = 1.239，95% CI = 1.105 - 1.513，p = 0.035）。
该荟萃分析表明，IL-10基因多态性与血管炎易感性相关，尤其是在WG和BD中。
