Proietto Laura R, Plummer Caryn E, Maxwell Kathleen M, Lamb Kenneth E, Brooks Dennis E
SACS, University of Florida, 2015 SW 16th Avenue, Gainesville, FL, 32608, USA.
Small Animal Clinical Sciences, University of Florida, PO Box 100101, Gainesville, FL, 32610-0101, USA.
Vet Ophthalmol. 2016 Jul;19(4):291-6. doi: 10.1111/vop.12297. Epub 2015 Jul 27.
The purpose of this investigation was to identify potential environmental risk factors for the diagnosis of equine deep stromal abscesses (DSA) in the subtropical climate at the University of Florida Veterinary Medical Center (UFVMC).
Cases included were selected from the UFVMC medical record and imaging database, and included all cases of equine DSA diagnosed during the period from December 1991 to December 2013 in patients residing in north central Florida. Patient date of diagnosis and atmospheric data was obtained for north central Florida for the corresponding time period. Univariate and multivariate general linear models were generated testing effects and interactions between environmental conditions.
When year, sulfur dioxide (SO2 ) and wind were analyzed in the presence of each other, a one-mile per hour increase in wind (P = 0.005) significantly increased the number of DSA cases by 1.63 cases per year. When the influence of temperature was evaluated in conjunction with year and nitrogen dioxide (NO2 ), the number of cases decreased by 0.1534 per year for every degree increase in temperature (°C) (P = 0.039).
Wind speed is the first significant atmospheric risk factor to be identified for DSA formation in the horse. The importance of environmental variance in the incidence of DSA indicates that the pathogenesis of DSA formation may be multifactorial, interdependent and provides support in some horses for the micropuncture hypothesis of DSA formation related to the involvement of environmental conditions causing precorneal tear film and epithelial damage.
本研究旨在确定佛罗里达大学兽医学院（UFVMC）亚热带气候下马深部基质脓肿（DSA）诊断的潜在环境风险因素。
从UFVMC的病历和影像数据库中选取病例，包括1991年12月至2013年12月期间在佛罗里达州中北部居住的马匹中诊断出的所有DSA病例。获取佛罗里达州中北部相应时间段的患者诊断日期和大气数据。生成单变量和多变量一般线性模型，以测试环境条件之间的影响和相互作用。
当同时分析年份、二氧化硫（SO2）和风速时，风速每增加1英里/小时（P = 0.005），DSA病例数每年显著增加1.63例。当结合年份和二氧化氮（NO2）评估温度的影响时，温度每升高1摄氏度（°C），病例数每年减少0.1534例（P = 0.039）。
风速是首个被确定与马DSA形成相关的重要大气风险因素。DSA发病率中环境差异的重要性表明，DSA形成的发病机制可能是多因素的、相互依存的，并在一些马匹中为与环境条件导致角膜前泪膜和上皮损伤相关的DSA形成微穿刺假说提供了支持。
