Jiao Jian-tong, Sun Jun, Ma Jian-fen, Dai Min-chao, Huang Jin, Jiang Chen, Wang Cheng, Cheng Chao, Shao Jun-fei
Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214023, China.
J Neurooncol. 2015 Sep;124(3):475-84. doi: 10.1007/s11060-015-1861-7. Epub 2015 Jul 28.
Depression is found to be associated with up-regulation of inflammatory cytokines. However, the relationship in high grade glioma (HGG) patients is still unclear. In this prospective study, a total 132 HGG patients participated in blood sample collection for inflammatory cytokines detection by ELISA, mental status, quality of life (QOL) and physical functional status testing. The association between inflammatory cytokines and depression risk was assessed using conditional logistic regression. The incidences of depressive symptoms and depression in high grade glioama patients were 45.5 and 25 % respectively during 12 months follow-up. We found the risk of depression was elevated with increased C-reactive protein (CRP) and interleukin-6 (IL-6) in high grade glioma patients after adjustment of confounders. The serum levels of CRP and IL-6 in patients with transient depression and depression were higher than those without depressive symptoms. In addition, depression had significant effects on the survival, QOL and physical functional status of patients. Depression is prevalent among patients with HGG. The present study suggests that serum CRP and IL-6 may serve as a depression marker for HGG patients. The survival and quality of life of HGG patients may be improved by an effective management for depression.
研究发现抑郁症与炎症细胞因子的上调有关。然而，其在高级别胶质瘤（HGG）患者中的关系仍不明确。在这项前瞻性研究中，共有132例HGG患者参与了血液样本采集，通过酶联免疫吸附测定法检测炎症细胞因子、评估精神状态、生活质量（QOL）和身体功能状态。使用条件逻辑回归评估炎症细胞因子与抑郁风险之间的关联。在12个月的随访期间，高级别胶质瘤患者抑郁症状和抑郁症的发生率分别为45.5%和25%。我们发现，在调整混杂因素后，高级别胶质瘤患者中，随着C反应蛋白（CRP）和白细胞介素-6（IL-6）水平升高，抑郁风险增加。短暂抑郁和抑郁患者的血清CRP和IL-6水平高于无抑郁症状的患者。此外，抑郁对患者的生存、生活质量和身体功能状态有显著影响。抑郁症在HGG患者中很普遍。本研究表明，血清CRP和IL-6可能作为HGG患者抑郁的标志物。对抑郁症进行有效管理可能会改善HGG患者的生存和生活质量。
