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1
Chemotherapy for Good-Risk Nonseminomatous Germ Cell Tumors: Current Concepts and Controversies.低危非精原细胞瘤性生殖细胞肿瘤的化疗：当前概念与争议
Urol Clin North Am. 2015 Aug;42(3):347-57. doi: 10.1016/j.ucl.2015.04.009.
2
Chemotherapy for good-risk germ cell tumors: current concepts and controversies.高危生殖细胞肿瘤的化疗：当前概念与争议
Urol Clin North Am. 2007 May;34(2):171-7; abstract viii-ix. doi: 10.1016/j.ucl.2007.03.001.
3
Refining the optimal chemotherapy regimen for good-risk metastatic nonseminomatous germ-cell tumors: a randomized trial of the Genito-Urinary Group of the French Federation of Cancer Centers (GETUG T93BP).优化低危转移性非精原细胞瘤生殖细胞肿瘤的最佳化疗方案：法国癌症中心联合会泌尿生殖组（GETUG T93BP）的一项随机试验
Ann Oncol. 2007 May;18(5):917-24. doi: 10.1093/annonc/mdm062. Epub 2007 Mar 9.
4
Long-term followup results of 1 cycle of adjuvant bleomycin, etoposide and cisplatin chemotherapy for high risk clinical stage I nonseminomatous germ cell tumors of the testis.睾丸高危临床I期非精原细胞瘤患者接受1周期博来霉素、依托泊苷和顺铂辅助化疗的长期随访结果
J Urol. 2008 Jan;179(1):163-6. doi: 10.1016/j.juro.2007.08.172. Epub 2007 Nov 14.
5
Randomized trial comparing bleomycin/etoposide/cisplatin with alternating cisplatin/cyclophosphamide/doxorubicin and vinblastine/bleomycin regimens of chemotherapy for patients with intermediate- and poor-risk metastatic nonseminomatous germ cell tumors: Genito-Urinary Group of the French Federation of Cancer Centers Trial T93MP.比较博来霉素/依托泊苷/顺铂与顺铂/环磷酰胺/阿霉素及长春花碱/博来霉素交替化疗方案治疗中高危和低危转移性非精原细胞瘤性生殖细胞肿瘤患者的随机试验：法国癌症中心联合会泌尿生殖组T93MP试验
J Clin Oncol. 2008 Jan 20;26(3):421-7. doi: 10.1200/JCO.2007.13.8461.
6
Rates of teratoma and viable cancer at post-chemotherapy retroperitoneal lymph node dissection after induction chemotherapy for good risk nonseminomatous germ cell tumors.对于低风险非精原性生殖细胞肿瘤，诱导化疗后行化疗后腹膜后淋巴结清扫术时的畸胎瘤和存活癌发生率。
J Urol. 2015 Feb;193(2):513-8. doi: 10.1016/j.juro.2014.08.081. Epub 2014 Aug 20.
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The impact of bleomycin on retroperitoneal histology at post-chemotherapy retroperitoneal lymph node dissection of good risk germ cell tumors.博来霉素对低危生殖细胞肿瘤化疗后腹膜后淋巴结清扫术的腹膜后组织学的影响。
J Urol. 2015 Feb;193(2):507-12. doi: 10.1016/j.juro.2014.09.090. Epub 2014 Sep 22.
8
Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882.依托泊苷、博来霉素联合高剂量或标准剂量顺铂用于高危恶性生殖细胞肿瘤儿童及青少年的随机对照化疗：一项儿科协作组研究——儿科肿瘤学组9049和儿童癌症组8882
J Clin Oncol. 2004 Jul 1;22(13):2691-700. doi: 10.1200/JCO.2004.08.015.
9
Effectiveness of carboplatin, etoposide, and bleomycin combination chemotherapy in good-prognosis metastatic testicular nonseminomatous germ cell tumors.
J Clin Oncol. 1991 Jan;9(1):62-9. doi: 10.1200/JCO.1991.9.1.62.
10
Are 3 cycles of bleomycin, etoposide and cisplatin or 4 cycles of etoposide and cisplatin equivalent optimal regimens for patients with good risk metastatic germ cell tumors of the testis? The need for a randomized trial.对于低风险转移性睾丸生殖细胞肿瘤患者，博来霉素、依托泊苷和顺铂的3个周期方案与依托泊苷和顺铂的4个周期方案是否为等效的最佳方案？是否需要进行一项随机试验？
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本文引用的文献

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Platinum Complexes-Induced Cardiotoxicity of Isolated, Perfused Rat Heart: Comparison of Pt(II) and Pt(IV) Analogues Versus Cisplatin.
Cardiovasc Toxicol. 2015 Jul;15(3):261-8. doi: 10.1007/s12012-014-9293-8.
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Longitudinal serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels in a population-based sample of long-term testicular cancer survivors.基于人群的长期睾丸癌幸存者的纵向血清睾酮、黄体生成素和卵泡刺激素水平。
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Cancer statistics, 2014.癌症统计数据，2014 年。
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A prospective study of cognitive function in men with non-seminomatous germ cell tumors.一项关于非精原细胞瘤生殖细胞肿瘤男性认知功能的前瞻性研究。
Psychooncology. 2014 Jun;23(6):626-33. doi: 10.1002/pon.3453. Epub 2013 Dec 16.
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The prevalence and correlates of supportive care needs in testicular cancer survivors: a cross-sectional study.睾丸癌幸存者的支持性护理需求的流行率及相关因素：一项横断面研究。
Psychooncology. 2013 Nov;22(11):2557-64. doi: 10.1002/pon.3323. Epub 2013 Jul 3.
6
Prevalence of the metabolic syndrome and cardiovascular disease risk in chemotherapy-treated testicular germ cell tumour survivors.化疗治疗的睾丸生殖细胞肿瘤幸存者中代谢综合征和心血管疾病风险的流行率。
Br J Cancer. 2013 Jul 9;109(1):60-7. doi: 10.1038/bjc.2013.226. Epub 2013 May 9.
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Effect of testicular germ cell tumor therapy on renal function.睾丸生殖细胞肿瘤治疗对肾功能的影响。
Urology. 2012 Sep;80(3):641-8. doi: 10.1016/j.urology.2012.04.064. Epub 2012 Jul 26.
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Impact of long-term serum platinum concentrations on neuro- and ototoxicity in Cisplatin-treated survivors of testicular cancer.长期血清铂浓度对顺铂治疗睾丸癌幸存者的神经毒性和耳毒性的影响。
J Clin Oncol. 2012 Jan 20;30(3):300-7. doi: 10.1200/JCO.2011.37.4025. Epub 2011 Dec 19.
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Longitudinal changes in cardiac function after cisplatin-based chemotherapy for testicular cancer.顺铂为基础的化疗治疗睾丸癌后心功能的纵向变化。
Ann Oncol. 2011 Oct;22(10):2286-93. doi: 10.1093/annonc/mdr408. Epub 2011 Aug 29.
10
A prospective study of cognitive complaints in patients with testicular cancer.前瞻性研究睾丸癌患者的认知主诉。
Clin Genitourin Cancer. 2011 Sep;9(1):6-13. doi: 10.1016/j.clgc.2011.04.002. Epub 2011 Jun 12.

低危非精原细胞瘤性生殖细胞肿瘤的化疗：当前概念与争议

Chemotherapy for Good-Risk Nonseminomatous Germ Cell Tumors: Current Concepts and Controversies.

作者信息

In Gino, Dorff Tanya

机构信息

Division of Medical Oncology, USC Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.

Division of Medical Oncology, USC Keck School of Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.

出版信息

Urol Clin North Am. 2015 Aug;42(3):347-57. doi: 10.1016/j.ucl.2015.04.009.

DOI:10.1016/j.ucl.2015.04.009
PMID:26216822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9484323/
Abstract

The rate of diagnosis of germ cell tumors has remained fairly constant. By the International Germ Cell Cancer Consensus Classification, roughly 60% of all metastatic germ cell tumors are classified as good risk. This group of patients has an excellent prognosis, with greater than 90% expectation of cure. Treatment standards have not changed much in recent years. This article focuses on key concepts in the development of the currently accepted first-line regimens and addresses some evolving areas of interest, if not controversy.

摘要

生殖细胞肿瘤的诊断率一直相当稳定。根据国际生殖细胞癌共识分类，所有转移性生殖细胞肿瘤中约60%被归类为低风险。这组患者预后良好，治愈率超过90%。近年来治疗标准变化不大。本文重点介绍目前被接受的一线治疗方案制定中的关键概念，并探讨一些即便存在争议但仍在不断发展的关注领域。