眼底照相和眼底自发荧光在诊断玻璃膜疣中的应用评估

An evaluation of fundus photography and fundus autofluorescence in the diagnosis of cuticular drusen.

作者信息

Høeg Tracy B, Moldow Birgitte, Klein Ronald, La Cour Morten, Klemp Kristian, Erngaard Ditte, Ellervik Christina, Buch Helena

机构信息

Department of Ophthalmology, Næstved Hospital, Næstved, Denmark The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Department of Ophthalmology, Næstved Hospital, Næstved, Denmark.

出版信息

Br J Ophthalmol. 2016 Mar;100(3):378-82. doi: 10.1136/bjophthalmol-2015-307197. Epub 2015 Jul 27.

DOI:10.1136/bjophthalmol-2015-307197

PMID:26216869

Abstract

PURPOSE

To examine non-mydriatic fundus photography (FP) and fundus autofluorescence (FAF) as alternative non-invasive imaging modalities to fluorescein angiography (FA) in the detection of cuticular drusen (CD).

METHODS

Among 2953 adults from the Danish Rural Eye Study (DRES) with gradable FP, three study groups were selected: (1) All those with suspected CD without age-related macular degeneration (AMD) on FP, (2) all those with suspected CD with AMD on FP and (3) a randomly selected group with early AMD. Groups 1, 2 and 3 underwent FA and FAF and group 4 underwent FAF only as part of DRES CD substudy. Main outcome measures included percentage of correct positive and correct negative diagnoses, Cohen's κ and prevalence-adjusted and bias-adjusted κ (PABAK) coefficients of test and grader reliability.

RESULTS

CD was correctly identified on FP 88.9% of the time and correctly identified as not being present 83.3% of the time. CD was correctly identified on FAF 62.0% of the time and correctly identified as not being present 100.0% of the time. Compared with FA, FP has a PABAK of 0.75 (0.60 to 1.5) and FAF a PABAK of 0.44 (0.23 to 0.95).

CONCLUSIONS

FP is a promising, non-invasive substitute for FA in the diagnosis of CD. FAF was less reliable than FP to detect CD.

摘要

目的

研究非散瞳眼底照相（FP）和眼底自发荧光（FAF）作为荧光素血管造影（FA）的替代非侵入性成像方式在检测表皮性玻璃膜疣（CD）中的应用。

方法

在丹麦农村眼病研究（DRES）中2953名有可分级FP的成年人中，选择了三个研究组：（1）所有在FP上疑似患有CD但无年龄相关性黄斑变性（AMD）的人；（2）所有在FP上疑似患有CD且伴有AMD的人；（3）一个随机选择的早期AMD组。第1、2和3组接受了FA和FAF检查，第4组仅作为DRES CD子研究的一部分接受了FAF检查。主要观察指标包括正确阳性和正确阴性诊断的百分比、检验和分级者可靠性的Cohen's κ系数以及患病率调整和偏差调整的κ（PABAK）系数。