Pope James M, Sepehrband Farshid, Suheimat Marwan, Verkicharla Pavan K, Kasthurirangan Sanjeev, Atchison David A
School of Optometry & Vision Science, Queensland University of Technology, Brisbane, Australia 2Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4759-66. doi: 10.1167/iovs.15-16430.
To compare lens dimensions and refractive index distributions in type 1 diabetes and age-matched control groups.
There were 17 participants with type 1 diabetes, consisting of two subgroups (7 young [23 ± 4 years] and 10 older [54 ± 4 years] participants), with 23 controls (13 young, 24 ± 4 years; 10 older, 55 ± 4 years). For each participant, one eye was tested with relaxed accommodation. A 3T clinical magnetic resonance imaging scanner was used to image the eye, employing a multiple spin echo (MSE) sequence to determine lens dimensions and refractive index profiles along the equatorial and axial directions.
The diabetes group had significantly smaller lens equatorial diameters and larger lens axial thicknesses than the control group (diameter mean ± 95% confidence interval [CI]: diabetes group 8.65 ± 0.26 mm, control group 9.42 ± 0.18 mm; axial thickness: diabetes group 4.33 ± 0.30 mm, control group 3.80 ± 0.14 mm). These differences were also significant within each age group. The older group had significantly greater axial thickness than the young group (older group 4.35 ± 0.26 mm, young group 3.70 ± 0.25 mm). Center refractive indices of diabetes and control groups were not significantly different. There were some statistically significant differences between the refractive index fitting parameters of young and older groups, but not between diabetes and control groups of the same age.
Smaller lens diameters occurred in the diabetes groups than in the age-matched control groups. Differences in refractive index distribution between persons with and without diabetes are too small to have important effects on instruments measuring axial thickness.
比较1型糖尿病组和年龄匹配的对照组的晶状体尺寸和折射率分布。
17名1型糖尿病患者，分为两个亚组（7名年轻患者[23±4岁]和10名老年患者[54±4岁]），另有23名对照组患者（13名年轻患者，24±4岁；10名老年患者，55±4岁）。对每位参与者的一只眼睛进行放松调节状态下的检测。使用3T临床磁共振成像扫描仪对眼睛进行成像，采用多自旋回波（MSE）序列来确定晶状体在赤道和轴向上的尺寸以及折射率分布。
糖尿病组晶状体的赤道直径明显小于对照组（直径平均值±95%置信区间[CI]：糖尿病组8.65±0.26mm，对照组9.42±0.18mm；轴向厚度：糖尿病组4.33±0.30mm，对照组3.80±0.14mm）。这些差异在每个年龄组内也很显著。老年组的轴向厚度明显大于年轻组（老年组4.35±0.26mm，年轻组3.70±0.25mm）。糖尿病组和对照组的中心折射率无显著差异。年轻组和老年组的折射率拟合参数之间存在一些统计学上的显著差异，但同年龄的糖尿病组和对照组之间无差异。
糖尿病组的晶状体直径小于年龄匹配的对照组。糖尿病患者和非糖尿病患者之间的折射率分布差异太小，对测量轴向厚度的仪器没有重要影响。
