Ungprasert Patompong, Thongprayoon Charat, Kittanamongkolchai Wonngarm, Srivali Narat, Cheungpasitporn Wisit
Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Department of medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Int J Rheum Dis. 2016 Aug;19(8):819-25. doi: 10.1111/1756-185X.12631. Epub 2015 Jul 28.
To investigate the association between giant cell arteritis (GCA) and risk of peripheral arterial disease (PAD).
We conducted a systematic review and meta-analysis of observational cohort studies that reported relative risks, hazard ratios or standardized incidence ratios with 95% confidence comparing PAD risk in patients with GCA versus non-GCA subjects. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird.
Four studies with 9789 patients with GCA and 236 728 controls were identified and included in our data analysis. The pooled risk ratio of PAD among patients with GCA compared with controls was 1.88 (95% CI 1.04-3.41). The statistical heterogeneity was high with an I(2) of 89%.
Our study demonstrated a statistically significant increased risk of PAD among patients with GCA.
探讨巨细胞动脉炎（GCA）与外周动脉疾病（PAD）风险之间的关联。
我们对观察性队列研究进行了系统评价和荟萃分析，这些研究报告了相对风险、风险比或标准化发病率比，并给出95%置信区间，以比较GCA患者与非GCA受试者的PAD风险。采用DerSimonian和Laird的随机效应、通用逆方差法计算合并风险比和95%置信区间。
共纳入4项研究，涉及9789例GCA患者和236728例对照，并纳入我们的数据分析。与对照组相比，GCA患者发生PAD的合并风险比为1.88（95%CI 1.04 - 3.41）。统计异质性较高，I²为89%。
我们的研究表明，GCA患者发生PAD的风险在统计学上显著增加。
