Bubnov Rostyslav V, Spivak Mykola Ya, Lazarenko Liudmyla M, Bomba Alojz, Boyko Nadiya V
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv, 03680 Ukraine ; Clinical Hospital "Pheophania" of State Affairs Department, Zabolotny Str., 21, Kyiv, 03680 Ukraine.
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154, Zabolotny St., Kyiv, 03680 Ukraine ; LCL "Diaprof", Svitlycky Str., 35, Kyiv, 04123 Ukraine.
EPMA J. 2015 Jul 14;6(1):14. doi: 10.1186/s13167-015-0036-0. eCollection 2015.
There is great interest in the interaction between diet and immune system and concomitantly in the potential of probiotic bacteria, especially given recent advances in understanding of gut microbiota effects on health in the context of microbiome research. Following our recent study on bacterial wall elasticity as a predictive measure of phagocytic cellular reactions and related outcomes, a question was raised regarding the scope of the application of these findings in various medical conditions in the context of predictive, preventive, and personalized medicine (PPPM). This summarizing review of the data describes the contributions, both observed and potential, of probiotics to the gut-brain axis and various medical conditions, including immune and atopic states, metabolic and inflammatory diseases-including liver disease and diabetes mellitus-cancer, and more. It also suggests novel insights for a number of beneficial applications of probiotics and advances in development of novel probiotic-based treatments and personalized diets, as well as application of sophisticated imaging techniques and nanobiotechnologies that can be adopted in the near future by innovative medical experts, warranting further research and practical translation.
人们对饮食与免疫系统之间的相互作用以及益生菌的潜在作用有着浓厚兴趣，特别是鉴于在微生物组研究背景下对肠道微生物群对健康影响的理解取得了最新进展。继我们最近关于细菌壁弹性作为吞噬细胞反应及相关结果预测指标的研究之后，在预测、预防和个性化医学（PPPM）背景下，这些发现应用于各种医疗状况的范围引发了一个问题。本数据综述总结了益生菌对肠道-脑轴及各种医疗状况（包括免疫和特应性状态、代谢和炎症性疾病，如肝病和糖尿病、癌症等）已观察到的及潜在的贡献。它还为益生菌的一些有益应用、新型益生菌疗法和个性化饮食的发展进展，以及创新医学专家在不久的将来可采用的先进成像技术和纳米生物技术的应用提出了新见解，值得进一步研究和实际转化。
