ABCB1基因多态性与急性淋巴细胞白血病易感性：一项荟萃分析。
ABCB1 polymorphism and susceptibility to acute lymphoblastic leukemia: a meta analysis.
作者信息
Zhang Haiyan, Zhang Zhen, Li Guang
机构信息
Gynaecology Ward-1, Linyi City People's Hospital Linyi 276000, Shandong Province, China.
Gastrointestinal Surgery, Linyi City People's Hospital Linyi276000, Shandong Province, China.
出版信息
Int J Clin Exp Med. 2015 May 15;8(5):7585-91. eCollection 2015.
BACKGROUND
A large body of studies has investigated the potential role of ABCB1 polymorphism in ALL susceptibility. However, the results are conflicting. The aim of the present meta-analysis was to define the effect of ABCB1 polymorphism on ALL risk.
METHODS
We identified 8 eligible studies involving 1,308 cases and 1,427 controls through searching PubMed and Enbase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the strength of the association with both fixed effects and random effect models.
RESULTS
We found ABCB1 polymorphism was associated with an increased risk of ALL under the homozygote genotypes (TT vs. CC: OR, 1.29, 95% CI, 1.08-1.54), the recessive model (TT vs. CT + CC: OR, 1.47, 95% CI, 1.02-2.13) and the allele model (T vs. C: OR, 1.14, 95% CI, 1.04-1.25). Similar results were indicated in Asian populations (TT vs. CC: OR, 1.79, 95% CI, 1.32-2.43; TT vs. CT + CC: OR, 2.55, 95% CI, 1.47-4.43; T vs. C: OR, 1.38, 95% CI, 1.18-1.62), but not in Caucasian populations.
CONCLUSIONS
These findings indicate that ABCB1 polymorphism may play a critical role in the development of ALL in Asians.
背景
大量研究探讨了ABCB1基因多态性在急性淋巴细胞白血病（ALL）易感性中的潜在作用。然而，结果相互矛盾。本荟萃分析的目的是确定ABCB1基因多态性对ALL风险的影响。
方法
通过检索PubMed和Embase数据库，我们确定了8项符合条件的研究，涉及1308例病例和1427例对照。采用比值比（OR）及95%置信区间（CI），通过固定效应模型和随机效应模型评估关联强度。
结果
我们发现，在纯合子基因型（TT与CC比较：OR，1.29，95%CI，1.08 - 1.54）、隐性模型（TT与CT + CC比较：OR，1.47，95%CI，1.02 - 2.13）和等位基因模型（T与C比较：OR，1.14，95%CI，1.04 - 1.25）下，ABCB1基因多态性与ALL风险增加相关。在亚洲人群中也得到了类似结果（TT与CC比较：OR，1.79，95%CI，1.32 - 2.43；TT与CT + CC比较：OR，2.55，95%CI，1.47 - 4.43；T与C比较：OR，1.38，95%CI，1.18 - 1.62），但在白种人群中未发现。
结论
这些发现表明，ABCB1基因多态性可能在亚洲人ALL的发生发展中起关键作用。
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