白细胞介素 1A(-889C/T) 多态性与慢性牙周炎易感性的关联：一项荟萃分析。
Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis.
机构信息
Department of Stomatology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, PR China.
Department of Oral and Maxillofacial Surgery, Beijing Stomatology Hospital Affiliated to Capital Medical University, Beijing 100050, PR China.
出版信息
Gene. 2020 Mar 1;729:144227. doi: 10.1016/j.gene.2019.144227. Epub 2019 Nov 21.
OBJECTIVE
The purpose of this study was to investigate the association between IL-1A (-889C/T, rs1800587) polymorphism and susceptibility of chronic periodontitis.
METHODS
A systematic literature search was carried out in the databases updated on July 1, 2019, including PubMed, Embase, Cochrane Library and Web of Science. Through STATA 14.0 software, the association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis was calculated by pooled odds rations (ORs) and 95% confidence intervals (CIs). Harbord test was used for the publication bias.
RESULTS
The results of overall meta-analysis revealed that IL-1A (-889C/T) polymorphism was associated with the susceptibility of chronic periodontitis among all the genetic models, including allele contrast [T vs. C, OR (95% CI): 1.297 (1.038-1.622), P = 0.022], dominant model [TT + CT vs. CC, OR (95% CI): 1.337 (1.015-1.761), P = 0.039], recessive model [TT vs. CC + CT, OR (95% CI): 1.453 (1.138-1.856), P = 0.003], and codominant model [TT vs. CC, OR (95% CI): 1.555 (1.187-2.038), P = 0.001; CT vs. CC, OR (95% CI): 2.559 (1.245-5.260), P = 0.011]. The results of subgroup analyses indicated that IL-1A (-889C/T) polymorphism was closely related to the susceptibility of chronic periodontitis in African population [T vs. C, OR (95% CI): 1.277 (1.039-1.571), P = 0.020; TT + CT vs. CC, OR (95% CI): 1.357 (1.061-1.735), P = 0.015; TT vs. CC, OR (95% CI): 1.599 (1.115-2.292), P = 0.011], in European population [TT vs. CC + CT, OR (95% CI): 1.645 (1.112-2.435), P = 0.013; TT vs. CC, OR (95% CI): 1.639 (1.044-2.574), P = 0.032] and in American population [CT vs. CC, OR (95% CI): 6.404 (3.000-13.669), P < 0.001].
CONCLUSIONS
IL-1A (-889C/T) polymorphism is associated with the susceptibility of chronic periodontitis in African, European and American populations according to the currently available evidence.
目的
本研究旨在探讨白细胞介素-1A（-889C/T，rs1800587）多态性与慢性牙周炎易感性的关系。
方法
系统检索了截至 2019 年 7 月 1 日更新的 PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库，采用 STATA 14.0 软件计算白细胞介素-1A（-889C/T）多态性与慢性牙周炎易感性的合并优势比（OR）和 95%置信区间（CI）。采用 Harbord 检验进行发表偏倚分析。
结果
总体荟萃分析结果显示，在所有遗传模型中，白细胞介素-1A（-889C/T）多态性与慢性牙周炎的易感性相关，包括等位基因对照[T 与 C，OR（95%CI）：1.297（1.038-1.622），P=0.022]、显性模型[TT+CT 与 CC，OR（95%CI）：1.337（1.015-1.761），P=0.039]、隐性模型[TT 与 CC+CT，OR（95%CI）：1.453（1.138-1.856），P=0.003]和共显性模型[TT 与 CC，OR（95%CI）：1.555（1.187-2.038），P=0.001；CT 与 CC，OR（95%CI）：2.559（1.245-5.260），P=0.011]。亚组分析结果表明，白细胞介素-1A（-889C/T）多态性与非洲人群慢性牙周炎的易感性密切相关[T 与 C，OR（95%CI）：1.277（1.039-1.571），P=0.020；TT+CT 与 CC，OR（95%CI）：1.357（1.061-1.735），P=0.015；TT 与 CC，OR（95%CI）：1.599（1.115-2.292），P=0.011]、欧洲人群[TT 与 CC+CT，OR（95%CI）：1.645（1.112-2.435），P=0.013；TT 与 CC，OR（95%CI）：1.639（1.044-2.574），P=0.032]和美洲人群[CT 与 CC，OR（95%CI）：6.404（3.000-13.669），P<0.001]。
结论
根据目前的证据，白细胞介素-1A（-889C/T）多态性与非洲、欧洲和美洲人群的慢性牙周炎易感性相关。
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