Abhyankar A, Bhambure N, Kamath N N, Pajankar S P, Nabar S T, Shrenivas A, Shah A C, Deshmukh S N
J Soc Occup Med. 1989 Winter;39(4):131-2. doi: 10.1093/occmed/39.4.131.
Fourteen cases, 5 with pre-existing COAD, exposed to up to 30 p.p.m. chlorine gas in an accidental leakage, were followed up clinically, radiologically and by spirometry at 2 weeks, 4 weeks, 8 weeks and 6 months. All the patients were asymptomatic by 2 weeks and did not reveal any radiological abnormality. The FVC, FEV1 and FVC observed/predicted improved at 4 weeks (p less than 0.05, p less than 0.05, p less than 0.01) and the improvement in FEF0.25-0.75 reached statistical significance (p less than 0.05) at 6 months. The mean improvement in FVC was 0.84 l and FEV1 was 0.6 l at 4 weeks. The 5 patients with pre-existing COAD did not show any evidence of additional lung damage. The observations have been consistent with acute tracheobronchitis with trends towards complete recovery.
14例患者，其中5例原有慢性阻塞性气道疾病（COAD），在一次意外泄漏事故中暴露于高达30 ppm的氯气中，分别于2周、4周、8周和6个月进行了临床、放射学和肺功能测定随访。所有患者在2周时均无症状，且未发现任何放射学异常。用力肺活量（FVC）、第一秒用力呼气容积（FEV1）以及实测FVC/预测FVC在4周时有所改善（p<0.05，p<0.05，p<0.01），而最大呼气中期流速（FEF0.25 - 0.75）在6个月时改善达到统计学意义（p<0.05）。4周时FVC平均改善0.84升，FEV1平均改善0.6升。5例原有COAD的患者未显示出任何额外肺损伤的证据。这些观察结果与急性气管支气管炎相符，且有完全恢复的趋势。
