Webb S M, Cabezas R, Montañés R, de Leiva A
Med Clin (Barc). 1989 Oct 28;93(13):501-2.
A female is reported with a pituitary tumor secreting growth hormone which remained active and induced invalidating headache in spite of previous treatment with surgery and radiotherapy. Treatment with the sustained action somatostatin analogue, SMS 201-995, was started and headache was improved in a matter of minutes, even if normalization of hormone hypersecretion was not demonstrated. The pathophysiological mechanisms possibly implicated in the improvement are discussed, and this therapeutic option in patients with headache unresponsive to common analgesics is emphasized.
据报道，一名女性患有分泌生长激素的垂体肿瘤，尽管此前接受了手术和放疗，但肿瘤仍有活性，并引发了使人衰弱的头痛。开始使用长效生长抑素类似物SMS 201-995进行治疗，头痛在几分钟内就得到了改善，即便激素分泌过多并未恢复正常。文中讨论了可能与病情改善有关的病理生理机制，并强调了这种治疗方法对于对普通镇痛药无反应的头痛患者的适用性。
