Cui Lin, Sun You-Hong, Chen Jue, Wang Lu, Liu Jian-Jun, Zhou Xiang-Rong, Ding Jie, Liu Xing-Xiang, Huang Xin-En
Department of Oncology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University, Taizhou, China E-mail :
Asian Pac J Cancer Prev. 2015;16(13):5477-82. doi: 10.7314/apjcp.2015.16.13.5477.
This study aimed to investigate the incidence and risk factors for a prethrombotic state in patients with malignant tumors.
Plasma d-dimer (D-D) in patients with malignant tumors was measured. Abnormal rates of D-D and possible risk factors like gender, age, type of tumor, and staging of tumor were analyzed.
Of 1,453 patients, 629 demonstrated plasma D-D abnormality (43.3%). The D-D abnormal rate of male patients (n=851, 43.5%) was not statistically significantly different from that for female patients (n=602, 43.0%) (p>0.05). D-D abnormal rate increased with age and was statistically significant among different age groups (p<0.05). Regarding staging of tumor, D-D abnormal rate in patients with phase I was 2.0%, 6.2% in phase II, 47.6% in phase III and 83.1% in phase IV, with statistically significant differences between phase III and II, as well as phase III and IV (p<0.01).
A prethrombotic state was closely related to malignancy of tumors. The risk factors for a prethrombotic state include age and tumor stage.
本研究旨在调查恶性肿瘤患者血栓前状态的发生率及危险因素。
检测恶性肿瘤患者血浆D-二聚体（D-D）水平。分析D-D异常率及性别、年龄、肿瘤类型、肿瘤分期等可能的危险因素。
1453例患者中，629例血浆D-D异常（43.3%）。男性患者（n = 851，43.5%）的D-D异常率与女性患者（n = 602，43.0%）相比，差异无统计学意义（p>0.05）。D-D异常率随年龄增加而升高，不同年龄组间差异有统计学意义（p<0.05）。肿瘤分期方面，Ⅰ期患者D-D异常率为2.0%，Ⅱ期为6.2%，Ⅲ期为47.6%，Ⅳ期为83.1%，Ⅲ期与Ⅱ期、Ⅲ期与Ⅳ期之间差异有统计学意义（p<0.01）。
血栓前状态与肿瘤恶性程度密切相关。血栓前状态的危险因素包括年龄和肿瘤分期。
