Lopez Benjamin J, Valentine Megan T
Department of Mechanical Engineering and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106-5070, USA.
Department of Mechanical Engineering and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106-5070, USA.
Biochim Biophys Acta. 2015 Nov;1853(11 Pt B):3015-24. doi: 10.1016/j.bbamcr.2015.07.016. Epub 2015 Jul 28.
In this article, we will summarize recent progress in understanding the mechanical origins of rigidity, strength, resiliency and stress transmission in the MT cytoskeleton using reconstituted networks formed from purified components. We focus on the role of network architecture, crosslinker compliance and dynamics, and molecular determinants of single filament elasticity, while highlighting open questions and future directions for this work.
在本文中，我们将总结利用由纯化成分形成的重构网络，在理解微管细胞骨架的刚性、强度、弹性和应力传递的力学起源方面取得的最新进展。我们重点关注网络结构、交联剂顺应性和动力学以及单丝弹性的分子决定因素的作用，同时突出这项工作中存在的未解决问题和未来方向。
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