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[心室辅助装置——长期机械循环支持的可能性]

[Ventricular assist device – Possibilities of long-term mechanical circulatory support].

作者信息

Englberger Lars, Reineke David C, Martinelli Michele V, Mohacsi Paul, Carrel Thierry P

机构信息

1 Universitätsklinik für Herz- und Gefässchirurgie, Schweizer Herz- und Gefässzentrum, Inselspital Bern.

出版信息

Ther Umsch. 2015 Aug;72(8):505-11. doi: 10.1024/0040-5930/a000707.

Abstract

In Switzerland 200’000 people suffer from congestive heart failure. Approximately 10’000 patients find themselves in an advanced state of the disease. When conservative treatment options are no longer available heart transplantation is the therapy of choice. Should this not be an option due to long waiting lists or medical issues assist device therapy becomes an option. Assist device therapy is separated in short-term and long-term support. Long-term support is nowadays performed with ventricular assist devices (VADs). The native heart is still in place and supported in parallel to the remaining function of the heart. The majority of patients are treated with a left ventricular assist device (LVAD). The right ventrical alone (RVAD) as well as bi-ventricular support (BiVAD) is rarely needed. The modern VADs are implantable and create a non-pulsative bloodflow. A percutaneous driveline enables energy supply and pump-control. Indication strategies for VAD implantations include bridge to transplant (short term support), bridge to candidacy and bridge to transplant. VADs become more and more a definite therapeutic option (destination therapy). VAD therapy might be a realistic alternative to organ transplantation in the near future.

摘要

在瑞士,有20万人患有充血性心力衰竭。约1万名患者处于该病的晚期。当保守治疗不再可行时,心脏移植是首选治疗方法。若因等待名单过长或医疗问题无法进行心脏移植,辅助装置治疗就成为一种选择。辅助装置治疗分为短期支持和长期支持。如今,长期支持通过心室辅助装置(VAD)来实现。天然心脏仍保留原位,并在心脏剩余功能的基础上得到辅助。大多数患者接受左心室辅助装置(LVAD)治疗。单独使用右心室辅助装置(RVAD)以及双心室支持(BiVAD)的情况很少见。现代VAD是可植入的,能产生非搏动性血流。经皮驱动线可实现能量供应和泵控制。VAD植入的适应证策略包括过渡到移植(短期支持)、过渡到候选资格和过渡到移植。VAD越来越成为一种确定性的治疗选择(终末期治疗)。在不久的将来,VAD治疗可能成为器官移植的一种现实替代方案。

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