Ramos Dionei, Bertolini Giovana Navarro, Leite Marceli Rocha, Carvalho Junior Luiz Carlos Soares, da Silva Pestana Paula Roberta, dos Santos Vanessa Ribeiro, Fortaleza Ana Claudia de Souza, Rodrigues Fernanda Maria Machado, Ramos Ercy Mara Cipulo
Department of Physiotherapy, São Paulo State University, Presidente Prudente, Brazil.
Department of Motricity Sciences, São Paulo State University, Rio Claro, Brazil.
Int J Chron Obstruct Pulmon Dis. 2015 Jul 21;10:1403-7. doi: 10.2147/COPD.S69829. eCollection 2015.
Sarcopenia is characterized by a progressive and generalized decrease of strength and muscle mass. Muscle mass loss is prevalent in patients with chronic obstructive pulmonary disease (COPD) as a result of both the disease and aging. Some methods have been proposed to assess body composition (and therefore identify muscle mass loss) in this population. Despite the high accuracy of some methods, they require sophisticated and costly equipment.
The purpose of this study was to infer the occurrence of muscle mass loss measured by a sophisticated method (dual energy X-ray absorptiometry [DEXA]) using a more simple and affordable equipment (dynamometer).
Fifty-seven stable subjects with COPD were evaluated for anthropometric characteristics, lung function, functional exercise capacity, body composition, and peripheral muscle strength. A binary logistic regression model verified whether knee-extension strength (measured by dynamometry) could infer muscle mass loss (from DEXA).
Patients with decreased knee-extension strength were 5.93 times more likely to have muscle mass loss, regardless of sex, disease stage, and functional exercise capacity (P=0.045).
Knee-extension dynamometry was able to infer muscle mass loss in patients with COPD.
肌肉减少症的特征是力量和肌肉量进行性普遍下降。由于疾病和衰老，慢性阻塞性肺疾病（COPD）患者普遍存在肌肉量流失的情况。已经提出了一些方法来评估该人群的身体成分（从而识别肌肉量流失）。尽管有些方法准确性高，但它们需要复杂且昂贵的设备。
本研究的目的是使用更简单且价格合理的设备（测力计）推断通过复杂方法（双能X线吸收法[DEXA]）测量的肌肉量流失情况。
对57名稳定期COPD患者进行人体测量学特征、肺功能、功能运动能力、身体成分和外周肌肉力量评估。二元逻辑回归模型验证膝关节伸展力量（通过测力计测量）是否能推断肌肉量流失（通过DEXA测量）。
无论性别、疾病阶段和功能运动能力如何，膝关节伸展力量降低的患者发生肌肉量流失的可能性高5.93倍（P = 0.045）。
膝关节伸展测力计能够推断COPD患者的肌肉量流失情况。
